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MKNK2 and RBX1
Number of citations of the paper that reports this interaction (PubMedID
16856496
)
0
Data Source:
BioGRID
(two hybrid)
MKNK2
RBX1
Description
MAPK interacting serine/threonine kinase 2
ring-box 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Cytoplasm
Nuclear Body
PML Body
Nucleus
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
VCB Complex
Cullin-RING Ubiquitin Ligase Complex
Cul2-RING Ubiquitin Ligase Complex
Cul3-RING Ubiquitin Ligase Complex
Cul4A-RING E3 Ubiquitin Ligase Complex
Cul4B-RING E3 Ubiquitin Ligase Complex
Cul5-RING Ubiquitin Ligase Complex
Cul7-RING Ubiquitin Ligase Complex
Nuclear SCF Ubiquitin Ligase Complex
Cul4-RING E3 Ubiquitin Ligase Complex
Molecular Function
Protein Serine/threonine Kinase Activity
Calmodulin-dependent Protein Kinase Activity
Protein Binding
Calmodulin Binding
ATP Binding
Calcium-dependent Protein Serine/threonine Kinase Activity
Metal Ion Binding
Ubiquitin-protein Transferase Activity
Protein Binding
Transcription Factor Binding
Zinc Ion Binding
NEDD8 Transferase Activity
Ubiquitin Protein Ligase Binding
Ubiquitin-ubiquitin Ligase Activity
Protein-containing Complex Binding
Ubiquitin Protein Ligase Activity
NEDD8 Ligase Activity
Cullin Family Protein Binding
Biological Process
Regulation Of Translation
Protein Phosphorylation
Cell Surface Receptor Signaling Pathway
Peptidyl-serine Phosphorylation
Hemopoiesis
Intracellular Signal Transduction
Protein Autophosphorylation
Cellular Response To Arsenic-containing Substance
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
MAPK Cascade
Protein Polyubiquitination
Nucleotide-excision Repair, DNA Damage Recognition
Nucleotide-excision Repair, DNA Duplex Unwinding
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, Preincision Complex Stabilization
Nucleotide-excision Repair, Preincision Complex Assembly
Nucleotide-excision Repair, DNA Incision, 3'-to Lesion
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Nucleotide-excision Repair, DNA Incision
DNA Damage Response, Detection Of DNA Damage
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
Protein Neddylation
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Global Genome Nucleotide-excision Repair
Negative Regulation Of Canonical Wnt Signaling Pathway
Pathways
Recognition of DNA damage by PCNA-containing replication complex
Prolactin receptor signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
Vif-mediated degradation of APOBEC3G
Degradation of beta-catenin by the destruction complex
NOTCH1 Intracellular Domain Regulates Transcription
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Degradation of DVL
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
DNA Damage Recognition in GG-NER
Formation of Incision Complex in GG-NER
Dual Incision in GG-NER
Formation of TC-NER Pre-Incision Complex
Transcription-Coupled Nucleotide Excision Repair (TC-NER)
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Orc1 removal from chromatin
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Nonsyndromic cleft lip with or without cleft palate (
28087736
)
Alcohol use disorder (consumption score) (
30940813
)
Allergic rhinitis (
25085501
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Bipolar I disorder (
31043756
)
Crohn's disease (
22936669
)
Neuroticism (
29255261
)
Interacting Genes
11 interacting genes:
CUL2
EIF4E
EIF4G1
ESR1
ESR2
MAPK1
MAPK14
MAPK8
RBX1
RPL7A
VBP1
68 interacting genes:
APP
CAND1
CAND2
CCND1
CDC34
CDKN1B
COPS6
CRBN
CSNK1E
CUL1
CUL2
CUL3
CUL4A
CUL4B
CUL5
CUL7
DCAF1
DESI1
DTL
EP300
ERBIN
ERCC8
FBH1
FBXW8
FRZB
GHR
GLMN
GPS1
GRAP2
HAX1
KCTD17
KIDINS220
MAGEC2
MAP3K20
MAP3K7
MAPK8IP2
MKNK2
MYB
NTHL1
OS9
PML
PMM1
PRAME
RHOBTB3
RNF126
RPS6KB1
S100A12
SEPTIN3
SERTAD1
SFTPD
SKP1
SMAD3
TAB1
TRIM27
TRIM74
UBE2D1
UBE2D2
UBE2D3
UBE2E2
UBE2E3
UBE2G1
UBE2G2
UBE2L3
UBE2L6
UBE2M
UBE2R2
VHL
VRK2
Entrez ID
2872
9978
HPRD ID
05459
06794
Ensembl ID
ENSG00000099875
ENSG00000100387
Uniprot IDs
B3KS07
Q9HBH9
P62877
PDB IDs
2AC3
2AC5
2HW7
6CJ5
6CJE
6CJH
6CJW
6CJY
6CK3
6CK6
6CKI
1LDJ
1LDK
1U6G
2HYE
2LGV
3DPL
3DQV
3RTR
4F52
4P5O
5N4W
Enriched GO Terms of Interacting Partners
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Tagcloud (Intersection)
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