GRK6 and KCNIP3

Number of citations of the paper that reports this interaction (PubMedID 17102134)
26

Data Source:
BioGRID (pull down, affinity chromatography technology, enzymatic study)

		GRK6	KCNIP3
Description		G protein-coupled receptor kinase 6	potassium voltage-gated channel interacting protein 3
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GO Annotations	Cellular Component	Plasma Membrane Membrane	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus
	Molecular Function	G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding
	Biological Process	Protein Phosphorylation G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Wnt Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport
Pathways		G alpha (s) signalling events	Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Blood protein levels ( 28240269) Cardiac troponin-I levels ( 31014085) Chronic kidney disease ( 20383146) Extremely high intelligence ( 29520040) Glycine levels ( 30837465) Intelligence (MTAG) ( 29326435) Metabolite levels ( 22916037) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		19 interacting genes: ADRB2 BDKRB2 CHRM3 EDNRA EDNRB FBXO7 FSHR GIT1 ITGA5 KCNIP3 LTB4R PRSS23 RCVRN RHO SLC9A3R1 SNCA SNCB SNCG TBXA2R	18 interacting genes: CALM2 CASP3 CD177 CLN3 CREB1 CREM CTBP2 GRK2 GRK6 IGF1R IGLV3-25 IL6ST MAVS PCBD2 PPP3CA PSEN1 PSEN2 TARBP2
Entrez ID		2870	30818
HPRD ID		02925	05232
Ensembl ID		ENSG00000198055	ENSG00000115041
Uniprot IDs		B3KPS5 P43250	A0A024RE22 Q9Y2W7
PDB IDs		2ACX 3NYN 3NYO	2E6W
Enriched GO Terms of Interacting Partners?
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