ANK2 and NRCAM

Number of citations of the paper that reports this interaction (PubMedID 11449000)
31

Data Source:
HPRD (in vitro)

		ANK2	NRCAM
Description		ankyrin 2	neuronal cell adhesion molecule
Image
GO Annotations	Cellular Component	Cell Mitochondrion Lysosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Intercalated Disc Membrane Basolateral Plasma Membrane Apical Plasma Membrane Z Disc T-tubule M Band A Band Sarcolemma Costamere Axon Initial Segment Membrane Raft Postsynaptic Membrane Recycling Endosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuron Projection Axon Initial Segment Glutamatergic Synapse Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Kinase Binding Spectrin Binding Protein Binding, Bridging Ion Channel Binding ATPase Binding Phosphorylation-dependent Protein Binding	Protein Binding Ankyrin Binding Protein Binding Involved In Heterotypic Cell-cell Adhesion
	Biological Process	Regulation Of Heart Rate Atrial Septum Development Cellular Calcium Ion Homeostasis ER To Golgi Vesicle-mediated Transport Endocytosis Cytoskeleton Organization Positive Regulation Of Gene Expression Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Protein Transport Paranodal Junction Assembly Regulation Of Protein Stability T-tubule Organization Protein Localization To Organelle Protein Localization To Cell Surface Cellular Protein Localization Protein Localization To M-band Protein Localization To T-tubule Positive Regulation Of Potassium Ion Transport Protein Stabilization Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Methylmercury Regulation Of Calcium Ion Transport Positive Regulation Of Calcium Ion Transport Regulation Of Cardiac Muscle Contraction Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Sarcoplasmic Reticulum Calcium Ion Transport Protein Localization To Endoplasmic Reticulum Protein Localization To Plasma Membrane Regulation Of Cardiac Muscle Cell Contraction Ventricular Cardiac Muscle Cell Action Potential Atrial Cardiac Muscle Cell Action Potential SA Node Cell Action Potential Membrane Depolarization During SA Node Cell Action Potential Atrial Cardiac Muscle Cell To AV Node Cell Communication SA Node Cell To Atrial Cardiac Muscle Cell Communication Regulation Of Heart Rate By Cardiac Conduction Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Calcium Ion Transmembrane Transporter Activity Positive Regulation Of Cation Channel Activity	Angiogenesis Neuron Migration Axonogenesis Axonal Fasciculation Synapse Assembly Central Nervous System Development Protein Localization Neuronal Action Potential Propagation Regulation Of Axon Extension Retinal Ganglion Cell Axon Guidance Heterotypic Cell-cell Adhesion Clustering Of Voltage-gated Sodium Channels Positive Regulation Of Neuron Differentiation Cell-cell Adhesion Regulation Of Postsynapse Organization
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins COPI-mediated anterograde transport	Interaction between L1 and Ankyrins NrCAM interactions Neurofascin interactions
Drugs
Diseases		Long QT syndrome, including: Romano-Ward syndrome; Jervell and Lange-Nielsen syndrome (JLNS)
GWAS		Blood trace element (Cu levels) ( 23720494) Body mass index ( 26426971) Chronotype ( 30696823) Diastolic blood pressure ( 31469255) Fractional exhaled nitric oxide (childhood) ( 24315451) Ischemic stroke ( 29531354) Parkinson's disease ( 28892059) Stroke ( 29531354)	Blood protein levels ( 30072576) Coffee consumption ( 21876539) Diastolic blood pressure ( 27841878) Femoral neck bone geometry and menarche (age at onset) ( 23593202) Systolic blood pressure ( 27841878) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) White matter hyperintensities in ischemic stroke ( 26674333) White matter hyperintensity burden ( 25663218)
Interacting Genes		18 interacting genes: DNAJB1 ECPAS EPB42 GABARAP GABARAPL1 GABARAPL2 L1CAM MAP1LC3A MAP1LC3B MAP1LC3C NDEL1 NRCAM OBSCN SIGMAR1 SPTBN1 TAF9 TNIK TP53	9 interacting genes: ANK2 CNTN2 ELOC HSPA12A LNX1 MACF1 MAGI3 NFASC PTPRB
Entrez ID		287	4897
HPRD ID		00110	07207
Ensembl ID		ENSG00000145362	ENSG00000091129
Uniprot IDs		Q01484	B7Z670 C9JYY6 Q14CA1 Q92823
PDB IDs		4D8O 4RLV 4RLY 5Y4D 5Y4E 5Y4F 5YIR 5YIS	1UEN 1UEY
Enriched GO Terms of Interacting Partners?
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