ANK1 and SPTAN1

Number of citations of the paper that reports this interaction (PubMedID 492324)
31

Data Source:
HPRD (in vitro)

		ANK1	SPTAN1
Description		ankyrin 1	spectrin alpha, non-erythrocytic 1
Image
GO Annotations	Cellular Component	Nucleus Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Spectrin-associated Cytoskeleton Membrane Basolateral Plasma Membrane Sarcoplasmic Reticulum Z Disc Axolemma M Band Sarcolemma Axon Initial Segment Postsynaptic Membrane	Extracellular Region Cytosol Spectrin Microtubule Cytoskeleton Membrane Specific Granule Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Extracellular Vesicle Tertiary Granule Lumen
	Molecular Function	Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Adaptor Activity Enzyme Binding Protein Phosphatase Binding Spectrin Binding Ion Channel Binding ATPase Binding	Actin Binding Structural Constituent Of Cytoskeleton Calcium Ion Binding Protein Binding Calmodulin Binding Cadherin Binding
	Biological Process	Exocytosis ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Signal Transduction Positive Regulation Of Organelle Organization Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Plasma Membrane	MAPK Cascade ER To Golgi Vesicle-mediated Transport Cytoskeleton Organization Axon Guidance Neutrophil Degranulation Actin Filament Capping
Pathways		Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins NrCAM interactions CHL1 interactions Neurofascin interactions Neurofascin interactions COPI-mediated anterograde transport	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport
Drugs
Diseases		Hereditary spherocytosis (SPH)	Early infantile epileptic encephalopathy; Ohtahara syndrome
GWAS		Birth weight ( 31043758 27680694) Corrected insulin response ( 24699409) Corrected insulin response adjusted for insulin sensitivity index ( 24699409) Glycated hemoglobin levels ( 24647736 20858683 31213470 28898252) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Insulin levels adjusted for BMI ( 24699409) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252) Mean corpuscular hemoglobin concentration ( 27863252 28017375) Mean corpuscular volume ( 27863252) Neutrophil percentage of white cells ( 27863252) Pulmonary function decline ( 22424883) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Sleep duration ( 30531941) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 26818947 30718926 28869590 22456796)	Axial length ( 24144296) Body mass index ( 26426971)
Interacting Genes		19 interacting genes: BLOC1S6 CD44 EPB42 HSPB1 ITPR3 KCTD6 L1CAM NBPF3 NFASC OBSCN RHAG RYR1 SLC4A1 SLC4A3 SPTA1 SPTAN1 SPTB TIAM1 TTN	56 interacting genes: ABI1 ABL1 ACP1 ACTA1 ACTB AKIP1 ANK1 CAPN1 CASP3 CASP7 CEP63 CNTRL CTNNA1 DDX24 DES EPB41 EPB41L2 EPB42 ERCC4 EVL EXOC1 FANCA FANCC GAP43 GRIA2 GRIN1 GRIN2A GRIN2B GRIN2D KALRN KARS1 MAPK6 NEFL PDE4D PIN4 PLEC PLEKHA5 PRKCB PTEN PTOV1 SHANK1 SHANK3 SLC9A2 SOS1 SPTB SPTBN1 SPTBN2 SPTBN4 SRC STAT1 SYN1 TAF1 TANC1 TES TSSC4 ZNF333
Entrez ID		286	6709
HPRD ID		01693	01684
Ensembl ID		ENSG00000029534	ENSG00000197694
Uniprot IDs		B3KX39 P16157	A0A384P5S9 Q13813
PDB IDs		1N11 2YQF 2YVI 3F59 3KBT 3KBU 3UD1 3UD2	2FOT 3F31 3FB2 5FW9 5FWB 5FWC
Enriched GO Terms of Interacting Partners?
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