GNG4 and ERO1B

		GNG4	ERO1B
Description		G protein subunit gamma 4	endoplasmic reticulum oxidoreductase 1 beta
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane G-protein Beta/gamma-subunit Complex Extracellular Exosome	Cell Endoplasmic Reticulum Endoplasmic Reticulum Membrane
	Molecular Function	GTPase Activity Protein Binding G-protein Beta-subunit Binding	Protein Disulfide Isomerase Activity Protein Binding Protein Disulfide Oxidoreductase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On A Sulfur Group Of Donors, Disulfide As Acceptor Unfolded Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Cell Growth	Protein Folding Peptidyl-proline Hydroxylation To 4-hydroxy-L-proline Protein Maturation By Protein Folding Insulin Processing Extracellular Matrix Organization Protein Folding In Endoplasmic Reticulum Glucose Homeostasis Cell Redox Homeostasis Oxidation-reduction Process
Pathways		Activation of G protein gated Potassium channels Glucagon signaling in metabolic regulation G-protein activation Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Glucagon-like Peptide-1 (GLP1) regulates insulin secretion ADP signalling through P2Y purinoceptor 12 G beta:gamma signalling through PI3Kgamma Prostacyclin signalling through prostacyclin receptor Prostacyclin signalling through prostacyclin receptor Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion Ca2+ pathway Ca2+ pathway G alpha (q) signalling events G alpha (12/13) signalling events G beta:gamma signalling through PLC beta G alpha (s) signalling events ADP signalling through P2Y purinoceptor 1 ADP signalling through P2Y purinoceptor 1 G alpha (i) signalling events G alpha (z) signalling events Glucagon-type ligand receptors Thromboxane signalling through TP receptor Vasopressin regulates renal water homeostasis via Aquaporins Thrombin signalling through proteinase activated receptors (PARs) Thrombin signalling through proteinase activated receptors (PARs) Presynaptic function of Kainate receptors Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding G beta:gamma signalling through BTK G beta:gamma signalling through CDC42 Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Insulin processing
Drugs			1-Ethyl-Pyrrolidine-2,5-Dione Flavin adenine dinucleotide
Diseases
GWAS		Aging traits ( 17903295) Cerebral amyloid deposition in APOEe4 non-carriers (PET imaging) ( 26252872) Type 2 diabetes ( 30297969)
Interacting Genes		9 interacting genes: ERO1B GNB1 GNB2 GNB3 GNB4 GNB5 RAF1 TFIP11 USHBP1	10 interacting genes: ACTL6A BRCA1 CNRIP1 ERP44 GNG4 HMGCS2 P4HB PARVA PYGM TARBP1
Entrez ID		2786	56605
HPRD ID		11978	13279
Ensembl ID		ENSG00000168243	ENSG00000086619
Uniprot IDs		B1APZ0 P50150	Q86YB8
PDB IDs
Enriched GO Terms of Interacting Partners?
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