GNAI2 and C5AR1

Number of citations of the paper that reports this interaction (PubMedID 7962171)
2

Data Source:
HPRD (in vitro)

		GNAI2	C5AR1
Description		G protein subunit alpha i2	complement C5a receptor 1
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Midbody Cell Body Membrane Raft Synapse Extracellular Exosome Extracellular Vesicle	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Basolateral Plasma Membrane Secretory Granule Membrane Intracellular Membrane-bounded Organelle Apical Part Of Cell
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Complement Component C5a Binding Complement Receptor Activity Complement Component C5a Receptor Activity G Protein-coupled Receptor Activity
	Biological Process	Adenosine Receptor Signaling Pathway Protein Folding Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Protein Tyrosine Phosphatase Activity Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Activation Of MAPK Activity Microglial Cell Activation Complement Receptor Mediated Signaling Pathway Apoptotic Process Chemotaxis Inflammatory Response Immune Response Cellular Defense Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Chemical Stimulus Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Cell Proliferation In Hindbrain Regulation Of Complement Activation Neutrophil Chemotaxis Animal Organ Regeneration Response To Peptidoglycan Response To Lipopolysaccharide Complement Component C5a Signaling Pathway MRNA Transcription By RNA Polymerase II Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Astrocyte Activation Positive Regulation Of Epithelial Cell Proliferation Defense Response To Gram-positive Bacterium Cognition Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Amyloid-beta Clearance Presynapse Organization Regulation Of Tau-protein Kinase Activity
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Regulation of Complement cascade
Drugs
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698)	Chronic periodontitis ( 25008200)
Interacting Genes		63 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	7 interacting genes: ARRB1 ARRB2 C5 C5AR2 GNAI2 RPS19 WAS
Entrez ID		2771	728
HPRD ID		00764	00224
Ensembl ID		ENSG00000114353	ENSG00000197405
Uniprot IDs		B3KP24 B3KX51 P04899	P21730
PDB IDs		6D9H	5O9H 6C1Q 6C1R
Enriched GO Terms of Interacting Partners?
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