GNAI2 and LHB

Number of citations of the paper that reports this interaction (PubMedID 8663226)
19

Data Source:
HPRD (in vitro)

		GNAI2	LHB
Description		G protein subunit alpha i2	luteinizing hormone subunit beta
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Centrosome Cytosol Heterotrimeric G-protein Complex Plasma Membrane Membrane Dendrite Midbody Cell Body Membrane Raft Synapse Extracellular Exosome Extracellular Vesicle	Extracellular Region Extracellular Space Cytoplasm Golgi Lumen
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding G-protein Beta/gamma-subunit Complex Binding Metal Ion Binding	Signaling Receptor Binding Hormone Activity
	Biological Process	Adenosine Receptor Signaling Pathway Protein Folding Cell Cycle Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity G Protein-coupled Acetylcholine Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Response To Nutrient Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Cell Migration Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Negative Regulation Of Calcium Ion-dependent Exocytosis Positive Regulation Of Insulin Receptor Signaling Pathway Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Calcium Ion Transport Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Protein Tyrosine Phosphatase Activity Positive Regulation Of Vascular Smooth Muscle Cell Proliferation Positive Regulation Of Neural Precursor Cell Proliferation Negative Regulation Of Apoptotic Signaling Pathway	Progesterone Biosynthetic Process Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Male Gonad Development Hormone-mediated Signaling Pathway Peptide Hormone Processing
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Androgen biosynthesis Mineralocorticoid biosynthesis Glycoprotein hormones Hormone ligand-binding receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production Reactions specific to the complex N-glycan synthesis pathway
Drugs
Diseases		Adrenal carcinoma
GWAS		Body mass index ( 26426971) Morning person ( 30696823) Sleep duration (short sleep) ( 30846698)	Blood protein levels ( 30072576 29875488 28240269)
Interacting Genes		63 interacting genes: ADCY1 ADORA1 ADRA2A ADRA2B ADRB2 AGTR2 C5AR1 CAV1 CCR5 CHRM1 CNR1 CXCL8 CXCR1 CXCR2 DRD2 EDNRA EGFR EYA1 EYA2 F2R FPR1 GNB2 GNB4 GPSM2 GPSM3 IGF1R ITCH KRT31 KRT40 KRTAP10-8 LHB LHCGR LPAR3 LTB4R MDFI MRGPRX1 MTNR1A MTNR1B NGB NOTCH2NLA NPM1 NUCB1 OPRD1 OPRM1 P2RY12 PLSCR1 PTEN PTPRU RASD1 RGS12 RGS14 RGS16 RGS18 RGS19 RGS20 RGS4 RGS5 RIC8A TBXA2R TRIP6 TSHR TTC1 TUBA4A	4 interacting genes: CGA GNAI2 GNAS LHCGR
Entrez ID		2771	3972
HPRD ID		00764	01072
Ensembl ID		ENSG00000114353	ENSG00000104826
Uniprot IDs		B3KP24 B3KX51 P04899	A0A0F7RQE6 P01229
PDB IDs		6D9H	1M92
Enriched GO Terms of Interacting Partners?
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