GNAI1 and S1PR3

Number of citations of the paper that reports this interaction (PubMedID 10488065)
76

Data Source:
HPRD (in vitro)

		GNAI1	S1PR3
Description		G protein subunit alpha i1	sphingosine-1-phosphate receptor 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Membrane Raft Extracellular Exosome Cell Cortex Region	Cell Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding	G Protein-coupled Receptor Activity Integrin Binding Protein Binding Lipid Binding Sphingosine-1-phosphate Receptor Activity
	Biological Process	Protein Folding Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Regulation Of CAMP-mediated Signaling Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex	Cytokine Production Sphingosine-1-phosphate Receptor Signaling Pathway Inflammatory Response G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Notch Signaling Pathway Positive Regulation Of Cell Proliferation Anatomical Structure Morphogenesis Regulation Of Interleukin-1 Beta Production Negative Regulation Of Establishment Of Endothelial Barrier
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	G alpha (i) signalling events Lysosphingolipid and LPA receptors Extra-nuclear estrogen signaling
Drugs		Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)	Cardiometabolic and hematological traits ( 27668658) Logical memory (delayed recall) in Alzheimer's disease dementia ( 29274321) Monocyte percentage of white cells ( 27863252) Response to statins (LDL cholesterol change) ( 22331829) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		58 interacting genes: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	4 interacting genes: GNA13 GNAI1 GNAQ HTR1A
Entrez ID		2770	1903
HPRD ID		00756	03572
Ensembl ID		ENSG00000127955	ENSG00000213694
Uniprot IDs		P63096	Q99500
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6N4B 6OS9 6OSA 6OT0 6QNO
Enriched GO Terms of Interacting Partners?
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