GNAI1 and ADCY5

Number of citations of the paper that reports this interaction (PubMedID 9748257)
34

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		GNAI1	ADCY5
Description		G protein subunit alpha i1	adenylate cyclase 5
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Lysosomal Membrane Centrosome Heterotrimeric G-protein Complex Plasma Membrane Midbody Membrane Raft Extracellular Exosome Cell Cortex Region	Cell Plasma Membrane Integral Component Of Plasma Membrane Cilium Integral Component Of Membrane Intermediate Filament Cytoskeleton
	Molecular Function	Magnesium Ion Binding G Protein-coupled Receptor Binding GTPase Activity Protein Binding GTP Binding GDP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding GTPase Activating Protein Binding	Adenylate Cyclase Activity ATP Binding Adenylate Cyclase Binding Metal Ion Binding Scaffold Protein Binding
	Biological Process	Protein Folding Cell Cycle G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Response To Peptide Hormone Regulation Of CAMP-mediated Signaling Negative Regulation Of Synaptic Transmission Cell Division Regulation Of Mitotic Spindle Organization Cellular Response To Forskolin Positive Regulation Of Protein Localization To Cell Cortex	Adenosine Receptor Signaling Pathway Renal Water Homeostasis CAMP Biosynthetic Process G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Locomotory Behavior Activation Of Protein Kinase A Activity Neuromuscular Process Controlling Balance Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Cellular Response To Glucagon Stimulus Cellular Response To Forskolin
Pathways		PLC beta mediated events PLC beta mediated events Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G-protein activation ADP signalling through P2Y purinoceptor 12 Adrenaline,noradrenaline inhibits insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events Regulation of insulin secretion Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Extra-nuclear estrogen signaling ADORA2B mediated anti-inflammatory cytokines production	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Adrenaline,noradrenaline inhibits insulin secretion G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Guanosine-5'-Diphosphate Tetrafluoroaluminate Ion	Colforsin 2',5'-DIDEOXY-ADENOSINE 3'-MONOPHOSPHATE
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Night sleep phenotypes ( 27126917) Post bronchodilator FEV1 ( 26634245)	Birth weight ( 23202124 31043758 27680694 20372150) Body mass index ( 25673413) Chronic kidney disease ( 26420894) Chronic obstructive pulmonary disease ( 30804561) Chronotype ( 30696823) Disease progression in age-related macular degeneration (adjusted for baseline) ( 29346644) Fasting blood glucose ( 25631608 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Gestational age at birth (maternal effect) ( 28877031) Glycated hemoglobin levels ( 28898252) Glycemic traits (pleiotropy) ( 31021400) Heel bone mineral density ( 30598549) Homeostasis model assessment of beta-cell function ( 20081858) Lipid traits (pleiotropy) (HIPO component 1) ( 30289880) Lymphocyte counts ( 27863252) Medication use (drugs used in diabetes) ( 31015401) Monocyte count ( 27863252) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653) Total cholesterol levels ( 29083408) Two-hour glucose challenge ( 20081857) Type 2 diabetes ( 22885922 24509480 30054458 22693455 29358691 30297969 28254843 26818947 28869590)
Interacting Genes		58 interacting genes: ADCY5 ADRA2A CCR5 CD47 CNR1 CRHR1 CXCR4 DRD3 EPOR ESR1 FFAR1 GNAO1 GNB2 GNB4 GPR1 GPR143 GPSM1 GPSM2 GPSM3 HRH4 HTR2A IGF1R KLHL3 MTNR1A MTNR1B NGB NUCB1 NUMA1 OPRD1 OPRM1 PDE6D PTEN PTPRU RANGAP1 RASD1 RGS10 RGS12 RGS14 RGS16 RGS17 RGS18 RGS19 RGS20 RGS4 RGS7 RIC8A S1PR1 S1PR2 S1PR3 S1PR4 S1PR5 SSTR2 SSTR3 STRN THAP7 TSHR VIPR1 WASF1	7 interacting genes: ADCY2 GNAI1 GNAS PRKACA PRKCA PRKCZ RGS2
Entrez ID		2770	111
HPRD ID		00756	08973
Ensembl ID		ENSG00000127955	ENSG00000173175
Uniprot IDs		P63096	A0A384P5Q5 B3KWA8 B7Z2C7 O95622
PDB IDs		1KJY 1Y3A 2G83 2GTP 2IK8 2OM2 2XNS 3ONW 3QE0 3QI2 3UMR 3UMS 4G5Q 5JS7 5JS8 5TDH 6CMO 6CRK 6DDE 6DDF 6N4B 6OS9 6OSA 6OT0 6QNO
Enriched GO Terms of Interacting Partners?
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