PRPF19 and PRCC

Number of citations of the paper that reports this interaction (PubMedID 22365833)
132

Data Source:
BioGRID (two hybrid, two hybrid)

		PRPF19	PRCC
Description		pre-mRNA processing factor 19	proline rich mitotic checkpoint control factor
Image			No pdb structure
GO Annotations	Cellular Component	Prp19 Complex Nucleus Nucleoplasm DNA Replication Factor A Complex Cytoplasm Lipid Droplet Spindle Membrane Nuclear Speck Site Of Double-strand Break U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin-ubiquitin Ligase Activity Identical Protein Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Spliceosomal Tri-snRNP Complex Assembly Spliceosomal Complex Assembly Generation Of Catalytic Spliceosome For First Transesterification Step MRNA Splicing, Via Spliceosome Inner Cell Mass Cell Proliferation Transcription-coupled Nucleotide-excision Repair Double-strand Break Repair Via Nonhomologous End Joining Lipid Biosynthetic Process Proteasomal Protein Catabolic Process Cellular Protein Localization Positive Regulation Of Neuron Differentiation Positive Regulation Of MRNA Splicing, Via Spliceosome Positive Regulation Of Astrocyte Differentiation Protein K63-linked Ubiquitination Signal Transduction Involved In DNA Damage Checkpoint	MRNA Splicing, Via Spliceosome Mitotic Cell Cycle Checkpoint
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER mRNA Splicing - Major Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases			Renal cell carcinoma
GWAS			SjÃ¶gren's syndrome ( 28076899)
Interacting Genes		14 interacting genes: DDX42 DNTT EGLN3 ESR1 EXOC7 GSTK1 HSPB1 POLR2A PRCC PRPF8 PSMB4 RPA3 U2AF1 UBE2D3	10 interacting genes: CSNK2A1 EGFR HOMER3 LSM2 MAD2L2 PPIL2 PRPF19 RBM10 SRSF2 TOE1
Entrez ID		27339	5546
HPRD ID		12214	01562
Ensembl ID		ENSG00000110107	ENSG00000143294
Uniprot IDs		Q9UMS4	A0A0S2Z456 A0A0S2Z470 Q92733 Q96FT4
PDB IDs		4LG8 5MQF 5XJC 5YZG 5Z56 5Z57 6FF7 6ICZ 6ID0 6ID1 6QDV
Enriched GO Terms of Interacting Partners?
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