EIF3K and CCND3

Number of citations of the paper that reports this interaction (PubMedID 15327989)
7

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		EIF3K	CCND3
Description		eukaryotic translation initiation factor 3 subunit K	cyclin D3
Image
GO Annotations	Cellular Component	Nucleus Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex Eukaryotic 48S Preinitiation Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Body
	Molecular Function	Translation Initiation Factor Activity Protein Binding Ribosome Binding	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Protein Phosphorylation Protein Phosphorylation Signal Transduction T Cell Proliferation Regulation Of Cell Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Insulin Receptor Signaling Pathway Cell Division Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit	Transcriptional regulation of white adipocyte differentiation MAPK6/MAPK4 signaling Cyclin D associated events in G1 Regulation of RUNX1 Expression and Activity
Drugs
Diseases
GWAS			Cardiometabolic and hematological traits ( 27668658) Crohn's disease ( 28067908) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 30275531) HDL cholesterol levels ( 28334899) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hematological parameters ( 19820697) High light scatter reticulocyte count ( 27863252) Inflammatory bowel disease ( 28067908) Mean corpuscular hemoglobin ( 29403010 28453575 20139978 27863252 28017375 19862010) Mean corpuscular hemoglobin concentration ( 28017375) Mean corpuscular volume ( 23263863 29403010 28453575 20139978 27863252 28017375 19862010) Metabolite levels (5-HIAA/ MHPG Ratio) ( 23319000) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Neutrophil count ( 21507922) Red blood cell count ( 29403010 20139978 27863252 28017375) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		7 interacting genes: CCND3 EIF3C EIF3G EIF3H EIF3J EIF3L SPP1	46 interacting genes: AKAP8 APP AREG ATF5 ATP5F1C CASP2 CDK11B CDK14 CDK4 CDK6 CDKN1A CDKN1B CRABP2 DMRTB1 DMTF1 DTNBP1 EFEMP2 EIF3K ETV1 FAS FHL3 GC LSM3 MAF1 MAPK4 MAPK6 MCM10 MYB NCOA2 NME1 NPDC1 PCNA POLD1 POLR3GL PSMC1 QKI RARA RB1 RBL2 RUNX1 SH3GLB2 SIL1 TEX11 TFIP11 TSG101 VDR
Entrez ID		27335	896
HPRD ID		11740	00452
Ensembl ID		ENSG00000178982	ENSG00000112576
Uniprot IDs		K7EK53 K7ERF1 Q9UBQ5 U3LUI4	B3KP19 D6RI00 P30281 Q5T8J1
PDB IDs		1RZ4 3J8B 3J8C 6FEC	3G33
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?