MMADHC and MMACHC

Number of citations of the paper that reports this interaction (PubMedID 21071249)
9

Data Source:
BioGRID (pull down, two hybrid)

		MMADHC	MMACHC
Description		metabolism of cobalamin associated D	metabolism of cobalamin associated C
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GO Annotations	Cellular Component	Cytoplasm Mitochondrion Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Oxidoreductase Activity Cobalamin Binding Demethylase Activity Cyanocobalamin Reductase (cyanide-eliminating) Activity Protein Homodimerization Activity Glutathione Binding FAD Binding
	Biological Process	Coenzyme Biosynthetic Process Cobalamin Metabolic Process Cofactor Metabolic Process	Glutathione Metabolic Process Cobalamin Metabolic Process Cobalamin Biosynthetic Process Oxidation-reduction Process Demethylation
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC
Drugs			Cyanocobalamin Hydroxocobalamin
Diseases		Methylmalonic aciduria (MMA)	Methylmalonic aciduria (MMA)
GWAS		Daytime sleep phenotypes ( 27126917) Liver enzyme levels (alanine transaminase) ( 24124411)	Blood protein levels ( 28240269) Homocysteine levels ( 23824729)
Interacting Genes		2 interacting genes: MMACHC PRNP	1 interacting genes: MMADHC
Entrez ID		27249	25974
HPRD ID		10781	18585
Ensembl ID		ENSG00000168288	ENSG00000132763
Uniprot IDs		Q9H3L0	A0A0C4DGU2 Q9Y4U1
PDB IDs		5CUZ 5CV0	3SBY 3SBZ 3SC0 3SOM 5UOS
Enriched GO Terms of Interacting Partners?
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