MMACHC and MMADHC

Number of citations of the paper that reports this interaction (PubMedID 21071249)
9

Data Source:
BioGRID (pull down, two hybrid)

		MMACHC	MMADHC
Description		metabolism of cobalamin associated C	metabolism of cobalamin associated D
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GO Annotations	Cellular Component	Cytoplasm Cytosol	Cytoplasm Mitochondrion Cytosol
	Molecular Function	Protein Binding Oxidoreductase Activity Cobalamin Binding Demethylase Activity Cyanocobalamin Reductase (cyanide-eliminating) Activity Protein Homodimerization Activity Glutathione Binding FAD Binding	Protein Binding
	Biological Process	Glutathione Metabolic Process Cobalamin Metabolic Process Cobalamin Biosynthetic Process Oxidation-reduction Process Demethylation	Coenzyme Biosynthetic Process Cobalamin Metabolic Process Cofactor Metabolic Process
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC	Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD
Drugs		Cyanocobalamin Hydroxocobalamin
Diseases		Methylmalonic aciduria (MMA)	Methylmalonic aciduria (MMA)
GWAS		Blood protein levels ( 28240269) Homocysteine levels ( 23824729)	Daytime sleep phenotypes ( 27126917) Liver enzyme levels (alanine transaminase) ( 24124411)
Interacting Genes		1 interacting genes: MMADHC	2 interacting genes: MMACHC PRNP
Entrez ID		25974	27249
HPRD ID		18585	10781
Ensembl ID		ENSG00000132763	ENSG00000168288
Uniprot IDs		A0A0C4DGU2 Q9Y4U1	Q9H3L0
PDB IDs		3SBY 3SBZ 3SC0 3SOM 5UOS	5CUZ 5CV0
Enriched GO Terms of Interacting Partners?
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