SERP1 and SEC61A1

Number of citations of the paper that reports this interaction (PubMedID 10601334)
29

Data Source:
HPRD (in vivo)

		SERP1	SEC61A1
Description		stress associated endoplasmic reticulum protein 1	SEC61 translocon subunit alpha 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Ribosome Cytoplasmic Microtubule Integral Component Of Membrane	Endoplasmic Reticulum Sec61 Translocon Complex Endoplasmic Reticulum Membrane Cytosol Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Protein Binding	Signal Sequence Binding Calcium Channel Activity Protein Binding Protein Transmembrane Transporter Activity Ribosome Binding
	Biological Process	Skeletal System Development Glucose Metabolic Process Cellular Protein Modification Process Protein Glycosylation Plasma Membrane Organization Post-embryonic Development Multicellular Organism Aging Protein Transport Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Insulin Secretion IRE1-mediated Unfolded Protein Response Positive Regulation Of Translation Positive Regulation Of Organ Growth Muscle Organ Morphogenesis Positive Regulation Of Growth Hormone Secretion	Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Posttranslational Protein Targeting To Endoplasmic Reticulum Membrane Endoplasmic Reticulum Organization Posttranslational Protein Targeting To Membrane, Translocation Response To Interferon-gamma Pronephric Nephron Development Protein Targeting To ER Calcium Ion Transmembrane Transport
Pathways		XBP1(S) activates chaperone genes Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	ER-Phagosome pathway SRP-dependent cotranslational protein targeting to membrane
Drugs
Diseases
GWAS			Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Gestational age at birth (maternal effect) ( 28877031)
Interacting Genes		8 interacting genes: APP CANX LMNA SCNN1A SCNN1G SEC61A1 SEC61B TMEM79	9 interacting genes: ACAD9 BAG6 CALM1 GET3 HSPA5 MLH1 SEC61G SERP1 TNF
Entrez ID		27230	29927
HPRD ID		18037	15316
Ensembl ID		ENSG00000120742	ENSG00000058262
Uniprot IDs		Q9Y6X1	B3KME8 B3KNF6 P61619
PDB IDs
Enriched GO Terms of Interacting Partners?
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