CYTH4 and CNKSR1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CYTH4	CNKSR1
Description		cytohesin 4	connector enhancer of kinase suppressor of Ras 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytosol Plasma Membrane	Plasma Membrane Cell-cell Junction Cell Cortex
	Molecular Function	ARF Guanyl-nucleotide Exchange Factor Activity Protein Binding Lipid Binding	Protein Binding Protein Binding, Bridging
	Biological Process	Regulation Of ARF Protein Signal Transduction	Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction
Pathways		Intra-Golgi traffic	MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Signaling downstream of RAS mutants
Drugs
Diseases
GWAS		Response to methotrexate in juvenile idiopathic arthritis ( 24709693) Uterine fibroids ( 28836065)	Emphysema annual change measurement in smokers (percent low attenuation area) ( 31324189)
Interacting Genes		9 interacting genes: AMOTL2 CNKSR1 FOS IPCEF1 KIFC3 KRT15 KRT40 SNAPC5 TRIM54	19 interacting genes: ARHGEF1 BRAP CADM4 CYTH3 CYTH4 MAP2K2 MAP2K7 MAP3K10 PIN1 RAF1 RALGDS RASSF1 RHOA RHPN1 SASH1 SMAD4 STK3 STK4 ZDHHC17
Entrez ID		27128	10256
HPRD ID		07354	11937
Ensembl ID		ENSG00000100055	ENSG00000142675
Uniprot IDs		B4E2V8 Q9UIA0	B4DL25 G3V160 Q53GM7 Q969H4
PDB IDs			1WWV
Enriched GO Terms of Interacting Partners?
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