PABPC1 and STAU1

Number of citations of the paper that reports this interaction (PubMedID 15121898)
60

Data Source:
HPRD (in vitro)

		PABPC1	STAU1
Description		poly(A) binding protein cytoplasmic 1	staufen double-stranded RNA binding protein 1
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Membrane Cell Leading Edge Cytoplasmic Ribonucleoprotein Granule Extracellular Exosome Catalytic Step 2 Spliceosome Ribonucleoprotein Complex	Cytoplasm Endoplasmic Reticulum Rough Endoplasmic Reticulum Cytosol Microtubule Associated Complex Plasma Membrane Cytoplasmic Stress Granule Membrane Dendrite Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Cell Body Extracellular Exosome Glutamatergic Synapse
	Molecular Function	RNA Binding MRNA 3'-UTR Binding Protein Binding Protein C-terminus Binding Poly(A) Binding Poly(U) RNA Binding Translation Activator Activity	RNA Binding Double-stranded RNA Binding Protein Binding Protein Phosphatase 1 Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Splicing, Via Spliceosome MRNA Polyadenylation Translational Initiation Gene Silencing By RNA Regulation Of MRNA Stability Positive Regulation Of Viral Genome Replication Positive Regulation Of Translation MRNA Stabilization Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay	Viral Process Cellular Response To Oxidative Stress Positive Regulation Of Viral Genome Replication Positive Regulation By Virus Of Viral Protein Levels In Host Cell Modification Of Postsynaptic Structure Positive Regulation Of Long-term Synaptic Potentiation
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Deadenylation of mRNA AUF1 (hnRNP D0) binds and destabilizes mRNA Translation initiation complex formation Regulation of expression of SLITs and ROBOs Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Anger ( 24489884) Change in quality of life in response to fluticasone propionate/salmeterol in chronic obstructive pulmonary disease ( 31299468) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196 25282103) Intelligence (MTAG) ( 29326435) Loneliness ( 31518406 29970889) Loneliness (MTAG) ( 29970889) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		52 interacting genes: ANAPC5 APBB1 ATP6V1C1 ATXN2 CARM1 CHAF1A CNOT6 CNOT7 CSDE1 DCAF13 EIF4B EIF4G1 EIF4G3 GSPT1 GSPT2 HBB HNRNPD HNRNPK IL7R ITCH LRP12 LRP1B MAPKAPK2 MET NDRG1 NFX1 ODF1 PAIP1 PAIP2 PAIP2B PAN2 PAN3 PCBP1 PCBP2 PCED1A PCSK7 PIN1 PITPNA PRMT6 PXN RACK1 RBM4 RIMS2 SREK1 STAU1 SYCP3 SYNCRIP TERT TOB1 U2AF1 WBP4 YWHAG	40 interacting genes: APP CASC3 CDC42 CSNK2B DHX9 DYNC1I1 FMR1 GLRX3 HNRNPU INA IQGAP1 KIF2B LONRF1 MAP1B MAPT MYH1 NCBP1 NCL NXT1 PABPC1 PABPN1 PPP1CA PPP1CC RAC1 RASA1 ROCK2 RPL28 RPL6 RPL7A RPLP0 RPS6 SPP1 SRPK1 TAX1BP3 TINCR TUBB TUBB4A UBE2D3 UPF1 ZMAT3
Entrez ID		26986	6780
HPRD ID		05247	03422
Ensembl ID		ENSG00000070756	ENSG00000124214
Uniprot IDs		A0A024R9C1 P11940	B3KRE0 O95793 Q59F99 Q6PJX3
PDB IDs		1CVJ 1G9L 1JGN 1JH4 2K8G 2RQG 2RQH 2X04 3KTP 3KTR 3KUI 3KUJ 3KUR 3KUS 3KUT 3PKN 3PTH 4F02 4F25 4F26 5DX1 5DX8 5DXA 5LGP 5LGQ 5LGR 5LGS	4DKK 6HTU
Enriched GO Terms of Interacting Partners?
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