GHR and CUL5

Number of citations of the paper that reports this interaction (PubMedID 25505247)
9

Data Source:
BioGRID (unspecified method)

		GHR	CUL5
Description		growth hormone receptor	cullin 5
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Receptor Complex Growth Hormone Receptor Complex	Cytosol SCF Ubiquitin Ligase Complex Cullin-RING Ubiquitin Ligase Complex Cul5-RING Ubiquitin Ligase Complex Site Of DNA Damage
	Molecular Function	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Cytokine Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding	Ubiquitin-protein Transferase Activity Calcium Channel Activity Protein Binding Ubiquitin Protein Ligase Binding Signaling Receptor Activity
	Biological Process	Activation Of MAPK Activity Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Positive Regulation Of JAK-STAT Cascade Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Ubiquitin-dependent Protein Catabolic Process Viral Process Protein Ubiquitination SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process ERBB2 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Calcium Ion Transmembrane Transport Intrinsic Apoptotic Signaling Pathway
Pathways		Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	Vif-mediated degradation of APOBEC3G Downregulation of ERBB2 signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Somatotropin Pegvisomant
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Blood protein levels ( 30072576 29875488) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 28552196 25429064 31562340) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Interacting Genes		45 interacting genes: AP2A1 BTRC CISH CLCC1 CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2	34 interacting genes: ANAPC11 CBFB CCNDBP1 COMMD1 COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A COPS8 DCUN1D1 DDX10 DEPTOR ELOA ERCC6 GHR GOLGA2 GPS1 PRKACA PTPN5 RBX1 RHOBTB1 RHOBTB2 RHOU RNF7 SMAD2 SMURF1 SOX30 TGFBR1 TRAF6 UBC UBE2F VHL
Entrez ID		2690	8065
HPRD ID		02971	03444
Ensembl ID		ENSG00000112964	ENSG00000166266
Uniprot IDs		A0A087X0H5 A0A087X162 P10912	Q93034
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD	3DPL 3DQV 4JGH 4N9F
Enriched GO Terms of Interacting Partners?
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