GHR and FBXO31

Number of citations of the paper that reports this interaction (PubMedID 25505247)
9

Data Source:
BioGRID (unspecified method)

		GHR	FBXO31
Description		growth hormone receptor	F-box protein 31
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Receptor Complex Growth Hormone Receptor Complex	Centrosome Cytosol SCF Ubiquitin Ligase Complex Neuronal Cell Body
	Molecular Function	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Cytokine Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding	Protein Binding Cyclin Binding
	Biological Process	Activation Of MAPK Activity Endocytosis JAK-STAT Cascade Cytokine-mediated Signaling Pathway Taurine Metabolic Process Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Positive Regulation Of JAK-STAT Cascade Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Growth Hormone Receptor Signaling Pathway JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway	Protein Polyubiquitination Cellular Response To DNA Damage Stimulus Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Post-translational Protein Modification Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Neuron Migration
Pathways		Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Somatotropin Pegvisomant
Diseases		Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD)
GWAS		Blood protein levels ( 30072576 29875488) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 28552196 25429064 31562340) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)	Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 22472876) Neurociticism ( 29500382) Neuroticism ( 29255261)
Interacting Genes		45 interacting genes: AP2A1 BTRC CISH CLCC1 CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2	5 interacting genes: AKT1 CCND1 CDT1 GHR MDM2
Entrez ID		2690	79791
HPRD ID		02971	10954
Ensembl ID		ENSG00000112964	ENSG00000103264
Uniprot IDs		A0A087X0H5 A0A087X162 P10912	A0A0C4DGU8 Q5XUX0
PDB IDs		1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD	5VZT 5VZU
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?