PTPN20 and ROR2

Number of citations of the paper that reports this interaction (PubMedID 28065597)
26

Data Source:
BioGRID (two hybrid)

		PTPN20	ROR2
Description		protein tyrosine phosphatase non-receptor type 20	receptor tyrosine kinase like orphan receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Microtubule Centriolar Satellite	Microtubule Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex
	Molecular Function	Protein Tyrosine Phosphatase Activity	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway
	Biological Process	Peptidyl-tyrosine Dephosphorylation Cellular Response To Cytokine Stimulus	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Smoothened Signaling Pathway JNK Cascade Multicellular Organism Development Nervous System Development Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Cell Migration BMP Signaling Pathway Embryonic Genitalia Morphogenesis Male Genitalia Development Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Embryonic Digit Morphogenesis Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Cell Fate Commitment Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Positive Regulation Of Synaptic Transmission, Glutamatergic Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Kinase C Activity Macrophage Migration
Pathways		Interleukin-37 signaling	PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases			Brachydactyly, including: type A; type B; type D; type E Robinow syndrome
GWAS			Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Type 2 diabetes ( 25483131)
Interacting Genes		6 interacting genes: AATK EGFR ERBB3 ERBB4 KIT ROR2	43 interacting genes: C1orf94 CDC14A CDC25C CRX DAB1 DAZAP2 DUPD1 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP6 ERBB2 EYA2 FZD2 FZD5 IKBKG ILKAP MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PPM1A PPM1B PPM1F PPP3CB PRR20A PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS STYX TAB1 TPTE WNT5A ZMYM4
Entrez ID		26095	4920
HPRD ID		10898	03822
Ensembl ID		ENSG00000204179	ENSG00000169071
Uniprot IDs		Q4JDK3 Q4JDL3 Q5H9Q9 Q9Y406	Q01974
PDB IDs			3ZZW 4GT4
Enriched GO Terms of Interacting Partners?
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