ROR2 and ZMYM4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ROR2	ZMYM4
Description		receptor tyrosine kinase like orphan receptor 2	zinc finger MYM-type containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Microtubule Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Axon Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Nucleus
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Smoothened Signaling Pathway JNK Cascade Multicellular Organism Development Nervous System Development Negative Regulation Of Cell Proliferation Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Cell Migration BMP Signaling Pathway Embryonic Genitalia Morphogenesis Male Genitalia Development Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Embryonic Digit Morphogenesis Regulation Of MAPK Cascade Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Cell Fate Commitment Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription, DNA-templated Anatomical Structure Development Positive Regulation Of Synaptic Transmission, Glutamatergic Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Kinase C Activity Macrophage Migration	Regulation Of Transcription By RNA Polymerase II Cytoskeleton Organization Multicellular Organism Development Regulation Of Cell Morphogenesis
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases		Brachydactyly, including: type A; type B; type D; type E Robinow syndrome
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Type 2 diabetes ( 25483131)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Night sleep phenotypes ( 27126917)
Interacting Genes		43 interacting genes: C1orf94 CDC14A CDC25C CRX DAB1 DAZAP2 DUPD1 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP6 ERBB2 EYA2 FZD2 FZD5 IKBKG ILKAP MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PPM1A PPM1B PPM1F PPP3CB PRR20A PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS STYX TAB1 TPTE WNT5A ZMYM4	7 interacting genes: CTCF FHL2 H3-4 ROR2 RUNX1T1 SRPK2 SUMO2
Entrez ID		4920	9202
HPRD ID		03822	10326
Ensembl ID		ENSG00000169071	ENSG00000146463
Uniprot IDs		Q01974	Q5VZL5
PDB IDs		3ZZW 4GT4
Enriched GO Terms of Interacting Partners?
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