CHMP2B and USP54

Number of citations of the paper that reports this interaction (PubMedID 19302785)
8

Data Source:
BioGRID (pull down)

		CHMP2B	USP54
Description		charged multivesicular body protein 2B	ubiquitin specific peptidase 54
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT III Complex Intracellular Cell Cytoplasm Lysosome Endosome Late Endosome Multivesicular Body Cytosol Plasma Membrane Postsynaptic Density Late Endosome Membrane Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Protein Domain Specific Binding Cadherin Binding	Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity
	Biological Process	Autophagy Nucleus Organization Endosome Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Endosomal Transport Macroautophagy Viral Life Cycle Endosome Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Late Endosome To Vacuole Transport Cognition Multivesicular Body-lysosome Fusion Midbody Abscission Neuron Cellular Homeostasis Regulation Of Modification Of Postsynaptic Structure Regulation Of Postsynapse Organization Regulation Of Mitotic Spindle Assembly Positive Regulation Of Viral Release From Host Cell ESCRT III Complex Disassembly	Protein Deubiquitination
Pathways		Budding and maturation of HIV virion Macroautophagy Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy Sealing of the nuclear envelope (NE) by ESCRT-III
Drugs
Diseases		Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Tourette's syndrome or obsessive-compulsive disorder ( 25158072)
Interacting Genes		12 interacting genes: ATP5F1C CENPF CHMP3 DPY30 FBXO7 MALSU1 PHGDH PNMA1 TERF2IP TRAF2 USP54 USP8	21 interacting genes: ARID5B ATN1 ATXN1 CDK19 CFAP70 CHMP1B CHMP2A CHMP2B CHMP4C COMTD1 EIF4E2 FAM149B1 FUT11 HK1 MSS51 MSX2 NXT2 PLCD1 SAMD8 TTYH1 UBC
Entrez ID		25978	159195
HPRD ID		13174	15641
Ensembl ID		ENSG00000083937	ENSG00000166348
Uniprot IDs		B2RE76 Q9UQN3	B7Z7X1 Q70EL1
PDB IDs		2JQK
Enriched GO Terms of Interacting Partners?
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