KANK2 and GPSM1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		KANK2	GPSM1
Description		KN motif and ankyrin repeat domains 2	G protein signaling modulator 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Mitochondrion	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Cortex Protein-containing Complex
	Molecular Function	Protein Binding	GDP-dissociation Inhibitor Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Apoptotic Process Negative Regulation Of Cell Proliferation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Regulation Of Rho Protein Signal Transduction Negative Regulation Of Programmed Cell Death Negative Regulation Of Vitamin D Receptor Signaling Pathway Kidney Epithelium Development Glomerular Visceral Epithelial Cell Migration Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle	Nervous System Development Positive Regulation Of Macroautophagy Cell Differentiation Negative Regulation Of GTPase Activity Negative Regulation Of Guanyl-nucleotide Exchange Factor Activity
Pathways			G alpha (i) signalling events
Drugs
Diseases
GWAS		Cholesterol, total ( 26780889) Coronary artery disease ( 29212778) HDL cholesterol ( 23505323) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Intraocular pressure ( 31959993) Red cell distribution width ( 27863252 28957414) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)	Acute insulin response (insulin secretion adjusted) ( 28490609) Birth weight ( 31043758) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Insulinogenic index ( 23263489) Joint damage in rheumatoid arthritis ( 26498133) Offspring birth weight ( 31043758) Type 2 diabetes ( 30297969 29632382 26818947 23945395 31118516 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 28067908) White blood cell count ( 29403010)
Interacting Genes		23 interacting genes: ABI3 CCDC33 CEP70 CSNK2A1 DYNLL1 EIF4E FHL2 GOLGA2 GPSM1 IHO1 LMO1 LMO2 LMO4 MAGEB4 MOB1A NCOA1 NOS3 PSEN1 SRPK2 STAC TLE5 TXLNA VPS52	12 interacting genes: CCDC158 DAZAP2 GNAI1 GNAI3 INSC KANK2 MAP1LC3A OSTM1 TRIP13 USHBP1 USP9X ZBED1
Entrez ID		25959	26086
HPRD ID		12463	17075
Ensembl ID		ENSG00000197256	ENSG00000160360
Uniprot IDs		Q63ZY3	A0A087WVF5 A0A0A0MRC4 A0A0A0MSK4 Q86YR5
PDB IDs		4HBD 5YBV
Enriched GO Terms of Interacting Partners?
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