POT1 and GRN

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		POT1	GRN
Description		protection of telomeres 1	granulin precursor
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Telomere Cap Complex Nuclear Chromosome, Telomeric Region Nucleoplasm Shelterin Complex	Extracellular Region Extracellular Space Cell Lysosome Lysosomal Membrane Endosome Late Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Plasma Membrane Membrane Azurophil Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding Telomerase Inhibitor Activity DEAD/H-box RNA Helicase Binding Telomeric DNA Binding Single-stranded Telomeric DNA Binding Telomeric D-loop Binding Telomeric G-quadruplex DNA Binding G-rich Strand Telomeric DNA Binding 8-hydroxy-2'-deoxyguanosine DNA Binding G-rich Single-stranded DNA Binding	RNA Binding Cytokine Activity Protein Binding Growth Factor Activity Chaperone Binding
	Biological Process	Telomere Maintenance Via Telomerase Telomere Capping Telomere Assembly Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Via Telomerase Positive Regulation Of Telomere Maintenance Via Telomerase DNA Duplex Unwinding Positive Regulation Of Helicase Activity Positive Regulation Of Telomerase Activity Negative Regulation Of Telomerase Activity Positive Regulation Of DNA Strand Elongation Telomeric D-loop Disassembly Establishment Of Protein Localization To Telomere Regulation Of DNA Helicase Activity Positive Regulation Of DNA Helicase Activity Regulation Of Double-strand Break Repair Via Nonhomologous End Joining	Astrocyte Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Lysosome Organization Lysosomal Transport Lysosomal Lumen Acidification Signal Transduction Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cell Migration Neutrophil Degranulation Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Angiogenesis Positive Regulation Of Axon Regeneration Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Protein Stabilization Regulation Of Nervous System Development Negative Regulation Of Respiratory Burst Involved In Inflammatory Response Positive Regulation Of Inflammatory Response To Wounding Positive Regulation Of Defense Response To Bacterium Negative Regulation Of Neutrophil Activation Positive Regulation Of Protein Folding Negative Regulation Of Microglial Cell Activation Positive Regulation Of Aspartic-type Peptidase Activity Positive Regulation Of Lysosome Organization
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Telomere Extension By Telomerase DNA Damage/Telomere Stress Induced Senescence	Neutrophil degranulation
Drugs
Diseases			Frontotemporal lobar degeneration (FTLD), including: Pick disease of brain; Frontotemporal dementia (FTD); Ubiquitin-positive frontotemporal dementia (UP-FTD); Progressive supranuclear palsy type 1 (PSNP1); Inclusion body myopathy with early-onset paget disease and frontotemporal dementia (IBMPFD); Frontotemporal dementia, chromosome 3-linked (FTD3)
GWAS		Chronic lymphocytic leukemia ( 28165464 24292274) Cutaneous malignant melanoma ( 26237428) Leukocyte telomere length ( 31171785) Response to selective serotonin reuptake inhibitors and depression ( 27622933)	Blood protein levels ( 30072576 29875488) Intracranial volume ( 22504418) Progranulin levels ( 29186428) Subcortical brain region volumes ( 25607358)
Interacting Genes		166 interacting genes: ACD ACOT7 ACTB ACTN4 ACY1 AFAP1L2 AHCY AHNAK AIPL1 ALDH1A1 ALDH3A1 AMPD2 ANKMY2 ANXA2 ANXA4 APPL2 ARHGDIA ARID3B ARRB1 BAG3 BCAS2 BIN2 C2orf74 CALD1 CAMK1D CCDC32 CCDC9 CCM2 CFL1 CFL2 CKB CLIC3 CNST CORO1A COX6A2 CPNE3 CPPED1 CRK CRYGS CSNK2B CYP4F11 DBN1 DBNL DCX DDX19B DNPH1 DOK2 DPP3 DPYSL3 ECI1 EEF1D EIF3G EIF4B ENO2 ENSA EPB41L1 EVL FAM131B FBP1 FES GAMT GAPDH GAS2L1 GFPT2 GNMT GPA33 GPR52 GRN H2AC20 HAAO HLCS HMOX1 HNMT HOXA3 HSP90AB1 HSPA1A IFRD2 IL1RN ISYNA1 IVL KHDRBS1 KIAA1191 KRT18 LAMC3 LASP1 LDHA LDHB MADD MAGEA4 MAP4 MAP4K2 MAP7 MDM2 MICA MT1X MVK MVP MYO5C NAP1L1 NCDN NOL3 NUDC NUDCD2 NXNL1 PACSIN1 PACSIN2 PAGE2 PAGE5 PAK4 PALM PCP4 PDE1B PDLIM2 PEX5 PFKP PGLS PGM1 PGM2 PHYHD1 PHYKPL PIPOX PRMT7 PROSER2 PYM1 RBKS RECQL4 RGS14 RHOU RIF1 RPAP1 RPSA RTN4 SARS1 SBDS SERTAD1 SH3BP1 SNCG STIP1 STUB1 SULT1B1 SULT1C2 SULT4A1 SYAP1 TAGLN TBCD TERF1 TMSB10 TMSB4Y TNKS TOMM34 TPI1 TPP1 TRIM16 TRIP10 TUBB2A TUBB4B TWF2 WIPI2 XAGE2 YWHAE YWHAG ZBED2 ZBTB49 ZFP36L1 ZNF32 ZNF790	38 interacting genes: ARFGAP1 ATN1 ATXN7 CACNA1A CCDC33 CCNG1 CCNT1 CDK9 CRKL CRY1 DLK1 DLX2 ELANE FAM131C FANCL FRAT1 GFI1B GLRX3 HK3 HOXA1 HSPG2 KRT18 KRTAP10-7 KRTAP26-1 NLK OTX1 PIK3R2 POT1 PRKAB2 RAC1 SGTA SLPI SMAD9 SPRY2 TAT TGM2 TOP3B YY1
Entrez ID		25913	2896
HPRD ID		07572	00733
Ensembl ID		ENSG00000128513	ENSG00000030582
Uniprot IDs		A0A024R739 A8MTK3 Q5MJ33 Q9NUX5	P28799
PDB IDs		1XJV 3KJO 3KJP 5H65 5UN7	1G26 2JYE 2JYT 2JYU 2JYV
Enriched GO Terms of Interacting Partners?
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