TRIM58 and DYNC1I1

Number of citations of the paper that reports this interaction (PubMedID 25241935)
25

Data Source:
BioGRID (enzymatic study)

		TRIM58	DYNC1I1
Description		tripartite motif containing 58	dynein cytoplasmic 1 intermediate chain 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Kinetochore Condensed Chromosome Kinetochore Spindle Pole Cell Nucleus Cytoplasm Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome
	Molecular Function	Molecular_function Zinc Ion Binding Dynein Heavy Chain Binding Dynein Intermediate Chain Binding Ubiquitin Protein Ligase Activity	Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Biological_process Protein Autoubiquitination Positive Regulation Of Erythrocyte Enucleation Regulation Of Nuclear Migration Along Microtubule	ER To Golgi Vesicle-mediated Transport Microtubule-based Movement Transport Along Microtubule Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Blood metabolite levels ( 26401656) Blood protein levels ( 28240269) Hemoglobin concentration ( 27863252) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Immature fraction of reticulocytes ( 27863252) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular hemoglobin concentration ( 29403010 27863252) Mean corpuscular volume ( 29403010 28453575 20139978 27863252 28017375) Mean platelet volume ( 27863252) Platelet count ( 22139419 29403010 27863252) Platelet distribution width ( 27863252) Red blood cell count ( 27863252) Red blood cell fatty acid levels ( 25500335) Red blood cell traits ( 23222517) Red cell distribution width ( 27863252 28957414) Response to serotonin reuptake inhibitors in major depressive disorder ( 25897834) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Systemic juvenile idiopathic arthritis ( 27927641) White blood cell count ( 27863252)	Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737) Obesity-related traits ( 23251661)
Interacting Genes		2 interacting genes: DYNC1I1 UBE2D3	32 interacting genes: ANXA7 BICD1 CADM4 CDKN1A DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 MCC NAGK NDEL1 NUDT21 NUP214 PIN1 RAP1GAP RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP
Entrez ID		25893	1780
HPRD ID		09825	04798
Ensembl ID		ENSG00000162722	ENSG00000158560
Uniprot IDs		Q8NG06	A4D1I7 O14576 Q8N542
PDB IDs
Enriched GO Terms of Interacting Partners?
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