DYNC1I1 and DYNLRB1

Number of citations of the paper that reports this interaction (PubMedID 16189514)
1016

Data Source:
BioGRID (two hybrid, proximity labelling technology)
HPRD (two hybrid)

		DYNC1I1	DYNLRB1
Description		dynein cytoplasmic 1 intermediate chain 1	dynein light chain roadblock-type 1
Image		No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Chromosome Kinetochore Spindle Pole Cell Nucleus Cytoplasm Cytosol Cytoplasmic Dynein Complex Microtubule Vesicle Cytoplasmic Ribonucleoprotein Granule Perinuclear Region Of Cytoplasm Recycling Endosome	Cytoplasm Centrosome Cytoplasmic Dynein Complex Microtubule Cilium Membrane Ciliary Tip
	Molecular Function	Motor Activity Microtubule Motor Activity Protein Binding Microtubule Binding Spectrin Binding Dynein Light Chain Binding Dynein Heavy Chain Binding	Microtubule Motor Activity Protein Binding Dynein Intermediate Chain Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Microtubule-based Movement Transport Along Microtubule Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Vesicle Transport Along Microtubule Positive Regulation Of ATP-dependent Microtubule Motor Activity, Plus-end-directed	Microtubule-based Movement Visual Behavior Intraciliary Transport Involved In Cilium Assembly
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase HCMV Early Events Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation	Intraflagellar transport
Drugs
Diseases
GWAS		Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 28552196) Immune reponse to smallpox (secreted IL-10) ( 22610502) Knee osteoarthritis ( 27696742) Multisite chronic pain ( 31194737) Obesity-related traits ( 23251661)	Bipolar disorder ( 31043756) Colorectal cancer or advanced adenoma ( 30510241) Pulse pressure ( 30224653)
Interacting Genes		32 interacting genes: ANXA7 BICD1 CADM4 CDKN1A DNM2 DYNLL1 DYNLL2 DYNLRB1 DYNLT1 DYNLT3 EMILIN1 FAM110A FAM83D FBP1 GRB7 GSK3B KAT7 MCC NAGK NDEL1 NUDT21 NUP214 PIN1 RAP1GAP RCC1 RUNDC3B SMN1 STAU1 TAOK1 TK1 TRIM58 WDCP	6 interacting genes: CPEB1 DYNC1I1 DYNC1I2 HSPH1 MPHOSPH6 MPP6
Entrez ID		1780	83658
HPRD ID		04798	06203
Ensembl ID		ENSG00000158560	ENSG00000125971
Uniprot IDs		A4D1I7 O14576 Q8N542	B4DFR2 Q9NP97
PDB IDs			1Z09 2B95 2E8J 2HZ5 6F1T 6F1Z 6F38 6F3A 6RLB 6SC2
Enriched GO Terms of Interacting Partners?
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