GAK and WFS1

		GAK	WFS1
Description		cyclin G associated kinase	wolframin ER transmembrane glycoprotein
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol Focal Adhesion Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Presynapse	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Integral Component Of Synaptic Vesicle Membrane Dendrite
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Clathrin Binding Cyclin Binding Chaperone Binding	Protein Binding Calmodulin Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Calcium-dependent Protein Binding ATPase Binding Proteasome Binding
	Biological Process	Protein Phosphorylation Receptor-mediated Endocytosis Endoplasmic Reticulum Organization Golgi Organization Cell Cycle Negative Regulation Of Neuron Projection Development Synaptic Vesicle Uncoating Protein Localization To Golgi Apparatus Chaperone Cofactor-dependent Protein Refolding Membrane Organization Clathrin Coat Disassembly Clathrin-dependent Endocytosis Protein Localization To Plasma Membrane Golgi To Lysosome Transport Clathrin-coated Pit Assembly	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Pancreas Development Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Olfactory Behavior Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of Type B Pancreatic Cell Apoptotic Process
Pathways		Golgi Associated Vesicle Biogenesis Clathrin-mediated endocytosis	XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases			Type II diabetes mellitus Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		HDL cholesterol ( 30275531) Mortality in sepsis ( 27639821) Parkinson's disease ( 20711177 21292315 25064009 27182965 22438815 21738487) Parkinson's disease (age of onset) ( 30957308) Parkinson's disease (familial) ( 18985386) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Primary biliary cholangitis ( 26394269) Triglycerides ( 30275531)	Cisplatin-induced ototoxicity ( 28039263) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 19734900 29632382 31118516 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		15 interacting genes: AP1M1 AP1M2 AP2M1 APP AR AXIN1 CCNG1 CDK5 CLTC CREBBP HSPA8 LRRK1 MFHAS1 USO1 WFS1	10 interacting genes: ADRA2C CD59 CSDE1 EIF6 FAM184B GAK MAPK6 S100P SMURF1 TERF1
Entrez ID		2580	7466
HPRD ID		03631	05864
Ensembl ID		ENSG00000178950	ENSG00000109501
Uniprot IDs		B4DS37 O14976	A0A0S2Z4V6 O76024
PDB IDs		4C57 4C58 4C59 4O38 4Y8D 5Y7Z 5Y80
Enriched GO Terms of Interacting Partners?
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