WFS1 and CSDE1

		WFS1	CSDE1
Description		wolframin ER transmembrane glycoprotein	cold shock domain containing E1
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Integral Component Of Synaptic Vesicle Membrane Dendrite	Golgi Apparatus Cytosol Plasma Membrane CRD-mediated MRNA Stability Complex
	Molecular Function	Protein Binding Calmodulin Binding Ubiquitin Protein Ligase Binding Activating Transcription Factor Binding Calcium-dependent Protein Binding ATPase Binding Proteasome Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Kidney Development Renal Water Homeostasis ER Overload Response Visual Perception Sensory Perception Of Sound Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Endoplasmic Reticulum Unfolded Protein Response Pancreas Development Positive Regulation Of Protein Ubiquitination Endoplasmic Reticulum Calcium Ion Homeostasis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Olfactory Behavior Glucose Homeostasis Negative Regulation Of Programmed Cell Death Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Growth Protein Stabilization Nervous System Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of Calcium Ion Transport Calcium Ion Homeostasis Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of ATF6-mediated Unfolded Protein Response Negative Regulation Of Type B Pancreatic Cell Apoptotic Process	Male Gonad Development Nuclear-transcribed MRNA Catabolic Process, No-go Decay
Pathways		XBP1(S) activates chaperone genes Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs
Diseases		Type II diabetes mellitus Wolfram syndrome (WFS); DIDMOAD syndrome
GWAS		Cisplatin-induced ototoxicity ( 28039263) Medication use (drugs used in diabetes) ( 31015401) Type 2 diabetes ( 22885922 24509480 30054458 29358691 30297969 19734900 29632382 31118516 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382)	Autism ( 24189344)
Interacting Genes		10 interacting genes: ADRA2C CD59 CSDE1 EIF6 FAM184B GAK MAPK6 S100P SMURF1 TERF1	22 interacting genes: C11orf68 CDC7 CTBS DOK1 DPYD FAM9B GCKR GCNT1 GFI1 HID1 HNRNPD IGFBP5 KCNMB4 PABPC1 PCSK7 SH3GLB1 SLIT2 SNRPB2 STT3A SYNCRIP WFS1 WNK1
Entrez ID		7466	7812
HPRD ID		05864	15949
Ensembl ID		ENSG00000109501	ENSG00000009307
Uniprot IDs		A0A0S2Z4V6 O76024	A0A024R0E2 A0A024R0K2 O75534
PDB IDs			1WFQ 1X65 2YTV 2YTX 2YTY
Enriched GO Terms of Interacting Partners?
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