RNF144B and USP15

Number of citations of the paper that reports this interaction (PubMedID 23105109)
16

Data Source:
BioGRID (two hybrid)

		RNF144B	USP15
Description		ring finger protein 144B	ubiquitin specific peptidase 15
Image		No pdb structure
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Cytoplasm Cytosol Integral Component Of Membrane Mitochondrial Membrane	Nucleus Cytoplasm Mitochondrion Cytosol
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Ubiquitin Conjugating Enzyme Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Process	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Protein Deubiquitination BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases
Drugs
Diseases
GWAS		Age at voice drop ( 27182965) Caudal middle frontal gyrus volume ( 31530798) Chronic periodontitis (mean interproximal clinical attachment level) ( 27601451) Chronotype ( 30696823) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Endometriosis ( 23472165) Facial morphology ( 31763980) General risk tolerance (MTAG) ( 30643258) Pulse pressure ( 30224653) Thiopurine S-methyltransferase activity ( 27770449)	Alopecia areata ( 25608926) Metabolite levels ( 23823483) Plateletcrit ( 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)
Interacting Genes		11 interacting genes: CDKN1A PAN2 UBC UBE2I UBE2L3 UBE2L6 UBE2T UBE2U UBE2Z USP15 USP2	47 interacting genes: BAP1 BMPR1A BRAP CARD9 CCDC57 DDX58 FHL1 H2BC21 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UBE2S UCHL1 UCHL3 USP14 USP20 USP21 USP28 USP33 USP51 USP8 YOD1
Entrez ID		255488	9958
HPRD ID		17126	05293
Ensembl ID		ENSG00000137393	ENSG00000135655
Uniprot IDs		Q7Z419	Q9Y4E8
PDB IDs			1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1
Enriched GO Terms of Interacting Partners?
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