USP15 and SENP8

Number of citations of the paper that reports this interaction (PubMedID 22626734)
5

Data Source:
BioGRID (enzymatic study)

		USP15	SENP8
Description		ubiquitin specific peptidase 15	SUMO peptidase family member, NEDD8 specific
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol	Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity	NEDD8-specific Protease Activity
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Viral Process Protein Deubiquitination BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway	Protein Deubiquitination Post-translational Protein Modification
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases	UCH proteinases Neddylation
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Plateletcrit ( 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)	Metabolite levels (HVA/MHPG ratio) ( 23319000)
Interacting Genes		47 interacting genes: BAP1 BMPR1A BRAP CARD9 CCDC57 DDX58 FHL1 H2BC21 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UBC UBE2S UCHL1 UCHL3 USP14 USP20 USP21 USP28 USP33 USP51 USP8 YOD1	13 interacting genes: COPS2 CUL1 CUL2 CUL4A GPS1 NEDD8 PLA2G2A SMURF1 TERF1 UBE2M USP15 USP21 USP28
Entrez ID		9958	123228
HPRD ID		05293	09784
Ensembl ID		ENSG00000135655	ENSG00000166192
Uniprot IDs		Q9Y4E8	A8K8D3 Q96LD8
PDB IDs		1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1	1XT9 2BKQ 2BKR
Enriched GO Terms of Interacting Partners?
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