GABPA and SP3

Number of citations of the paper that reports this interaction (PubMedID 11237613)
19

Data Source:
BioGRID (affinity chromatography technology, pull down)
HPRD (in vivo)

		GABPA	SP3
Description		GA binding protein transcription factor subunit alpha	Sp3 transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm PML Body Transcriptional Repressor Complex Protein-DNA Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Activating Transcription Factor Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blastocyst Formation Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mitochondrion Organization Positive Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dopamine	Negative Regulation Of Transcription By RNA Polymerase II Ossification Natural Killer Cell Differentiation Trophectodermal Cell Differentiation Liver Development Embryonic Placenta Development Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II B Cell Differentiation T Cell Differentiation Megakaryocyte Differentiation Monocyte Differentiation Lung Development Granulocyte Differentiation Enucleate Erythrocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Camera-type Eye Morphogenesis Embryonic Skeletal System Development Embryonic Process Involved In Female Pregnancy Definitive Hemopoiesis
Pathways		Transcriptional activation of mitochondrial biogenesis	SUMOylation of transcription factors
Drugs
Diseases
GWAS			End-stage renal disease in Type 1 diabetics ( 24029427) Lung cancer ( 28604730) Male-pattern baldness ( 27182965) Mosquito bite size ( 28199695) Otitis media (chronic/recurrent) ( 23974705) QT interval ( 24952745) Sensation seeking ( 30718321)
Interacting Genes		10 interacting genes: APP ATF1 CREBBP EP300 GABPB1 HCFC1 MED1 PINX1 SP1 SP3	23 interacting genes: AKT1 E2F1 EP300 ESR1 GABPA GCH1 GRIN1 HDAC1 HDAC2 HLTF NKX3-1 PIAS1 RB1 RBBP4 RPS20 SP1 STK19 SUMO1 TP53 TP73 UBE2I VEGFA ZBTB7A
Entrez ID		2551	6670
HPRD ID		11793	03483
Ensembl ID		ENSG00000154727	ENSG00000172845
Uniprot IDs		A8IE48 Q06546 Q8IYS3	B7ZLN9 Q02447 Q59FX5 Q86TP0
PDB IDs
Enriched GO Terms of Interacting Partners?
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