GABBR1 and CHFR

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
HPRD (two hybrid)

		GABBR1	CHFR
Description		gamma-aminobutyric acid type B receptor subunit 1	checkpoint with forkhead and ring finger domains
Image
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell Junction Dendrite G Protein-coupled Receptor Heterodimeric Complex Presynaptic Membrane Postsynaptic Membrane Schaffer Collateral - CA1 Synapse GABA-ergic Synapse	Nucleus PML Body
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	Nucleotide Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Regulation Of Postsynaptic Membrane Potential	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Mitotic Cell Cycle Checkpoint Protein Ubiquitination Modification-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Protein Destabilization Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cell Division
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs		Baclofen Progabide Gabapentin Vigabatrin Taurine gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Crohn's disease ( 22412388) Height ( 28552196) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Nasopharyngeal carcinoma ( 19664746) Nicotine dependence ( 28440896) Platelet count ( 26805783) Schizophrenia ( 27922604) Ulna and radius bone mineral density ( 30172743) White blood cell count ( 27863252)	Cognitive function ( 24684796) Height ( 31562340) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		11 interacting genes: ATF5 CHFR CPEB2 GABBR2 GNAO1 JAKMIP1 KCNJ6 MAX NSF RGS4 YWHAZ	30 interacting genes: AURKA BRD4 CBLC EEF1G GABBR1 GRB10 GRB14 HDAC1 HDAC2 ITGAE PML RNF125 RNF7 SIRT1 SMARCA4 SMARCB1 SMARCD1 TRIM9 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2I UBE2L1 UBE2N UBE2W WDR47
Entrez ID		2550	55743
HPRD ID		04644	05552
Ensembl ID		ENSG00000204681	ENSG00000072609
Uniprot IDs		A0A1U9X7R0 Q59HG8 Q5SUJ9 Q8IW08 Q9UBS5	Q96EP1
PDB IDs		4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6HKC	1LGP 1LGQ 2XOC 2XOY 2XOZ 2XP0
Enriched GO Terms of Interacting Partners?
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