GAB1 and ARHGAP32

Number of citations of the paper that reports this interaction (PubMedID 12819203)
21

Data Source:
HPRD (in vivo, two hybrid)

		GAB1	ARHGAP32
Description		GRB2 associated binding protein 1	Rho GTPase activating protein 32
Image
GO Annotations	Cellular Component	Cytosol Cell-cell Junction	Golgi Membrane Fibrillar Center Nucleoplasm Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Cell Cortex Endosome Membrane Postsynaptic Density Actin Cytoskeleton Cell Junction Dendritic Spine
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Cytoskeleton Reorganization Response To Hepatocyte Growth Factor Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase B Signaling Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants	Rho GTPase cycle
Drugs
Diseases
GWAS		Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Intracranial aneurysm ( 30823506) Iris color (L* coordinate) ( 29109912) Macular thickness ( 30535121) Metabolite levels (5-HIAA) ( 23319000)
Interacting Genes		36 interacting genes: ARHGAP32 C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FRS2 GAB2 GRAP2 GRB2 GTF2A1L INPP5D INSR JAK1 LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R PDGFRB PIK3CG PIK3R1 PLCG1 PLCG2 PTPN11 PTPN18 RET SHC1 SOS1 SYP TRIM15	33 interacting genes: ABI2 ATXN1 BCAR1 CAMK2N2 CDC42 CDH1 CDH2 CRK CRKL CTNNB1 DLG4 DZIP3 FYN GAB1 GAB2 GRAP GRB2 GRIN2A GRIN2B LZTS2 MDFI MEGF10 NCK1 NCK2 NPHP1 NTRK1 PIK3R1 PLCG1 RAC1 RHOA SHC3 SRC TLE5
Entrez ID		2549	9743
HPRD ID		05116	12257
Ensembl ID		ENSG00000109458	ENSG00000134909
Uniprot IDs		Q13480 Q9HA84	A7KAX9 Q86T64
PDB IDs		4QSY	3IUG
Enriched GO Terms of Interacting Partners?
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