GAB1 and MAPK4

Number of citations of the paper that reports this interaction (PubMedID 12008033)
13

Data Source:
HPRD (in vitro)

		GAB1	MAPK4
Description		GRB2 associated binding protein 1	mitogen-activated protein kinase 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Cell-cell Junction	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	SH3/SH2 Adaptor Activity Protein Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Angiogenesis Epidermal Growth Factor Receptor Signaling Pathway Axon Guidance Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Actin Cytoskeleton Reorganization Response To Hepatocyte Growth Factor Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Cell Migration By Vascular Endothelial Growth Factor Signaling Pathway ERBB2 Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Protein Kinase B Signaling Endothelial Cell Chemotaxis To Vascular Endothelial Growth Factor	MAPK Cascade Protein Phosphorylation Cell Cycle Regulation Of Gene Expression Intracellular Signal Transduction Cellular Response To Organic Substance
Pathways		PI3K Cascade Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants PIP3 activates AKT signaling GAB1 signalosome PI3K events in ERBB2 signaling Constitutive Signaling by Aberrant PI3K in Cancer Constitutive Signaling by EGFRvIII PI-3K cascade:FGFR1 PI-3K cascade:FGFR2 PI-3K cascade:FGFR3 PI-3K cascade:FGFR4 Signaling by FGFR2 in disease Signaling by FGFR4 in disease Signaling by FGFR1 in disease PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling MET activates PI3K/AKT signaling Signaling by FGFR3 fusions in cancer Signaling by FGFR3 point mutants in cancer RET signaling MET activates PTPN11 MET activates RAP1 and RAC1 MET receptor recycling Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Activated NTRK2 signals through PI3K Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants	MAPK6/MAPK4 signaling
Drugs
Diseases
GWAS		Asthma ( 21804548) Diastolic blood pressure ( 27841878) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Estimated glomerular filtration rate in non-diabetics ( 31451708) Height ( 31562340) Systolic blood pressure ( 27841878) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Diastolic blood pressure ( 28135244) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Large HDL particle concentration ( 29084231) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Normal facial asymmetry (angle of surface orientation score) ( 30631343) Phospholipid levels in large HDL ( 29084231) Phospholipid levels in medium HDL ( 29084231) Pulse pressure ( 27841878) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		36 interacting genes: ARHGAP32 C1QBP CRK CRKL EGFR EPOR ERBB2 FCGR2B FRS2 GAB2 GRAP2 GRB2 GTF2A1L INPP5D INSR JAK1 LAT2 MAP3K3 MAPK1 MAPK3 MAPK4 MARK2 MET MST1R PDGFRB PIK3CG PIK3R1 PLCG1 PLCG2 PTPN11 PTPN18 RET SHC1 SOS1 SYP TRIM15	6 interacting genes: CALML3 CCND3 CRK GAB1 GAB2 MAPKAPK5
Entrez ID		2549	5596
HPRD ID		05116	01497
Ensembl ID		ENSG00000109458	ENSG00000141639
Uniprot IDs		Q13480 Q9HA84	B4DEW2 K7ELV1 P31152
PDB IDs		4QSY
Enriched GO Terms of Interacting Partners?
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