ADAM2 and CD9

Number of citations of the paper that reports this interaction (PubMedID 10518536)
41

Data Source:
HPRD (in vivo)

		ADAM2	CD9
Description		ADAM metallopeptidase domain 2	CD9 molecule
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Protein-containing Complex	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion External Side Of Plasma Membrane Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Protein-containing Complex Extracellular Exosome Extracellular Vesicle
	Molecular Function	Metalloendopeptidase Activity Integrin Binding Metallopeptidase Activity	Integrin Binding Protein Binding
	Biological Process	Proteolysis Cell Adhesion Binding Of Sperm To Zona Pellucida Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Visual Learning Positive Regulation Of Gene Expression Adult Behavior	Platelet Degranulation Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Brain Development Negative Regulation Of Cell Proliferation Response To Water Deprivation Oligodendrocyte Development Myoblast Fusion Involved In Skeletal Muscle Regeneration Platelet Activation Paranodal Junction Assembly Receptor Internalization Sperm-egg Recognition Negative Regulation Of Cellular Component Movement Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Platelet Aggregation Regulation Of Macrophage Migration
Pathways		Interaction With Cumulus Cells And The Zona Pellucida	Platelet degranulation Acrosome Reaction and Sperm:Oocyte Membrane Binding Uptake and function of diphtheria toxin
Drugs			C31G
Diseases
GWAS		Restless legs syndrome ( 29029846)	Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Mean platelet volume ( 22139419 27863252) Paclitaxel-induced neuropathy ( 23776197) Platelet count ( 26805783 22139419)
Interacting Genes		2 interacting genes: CD9 CLGN	22 interacting genes: ADAM2 ADRB2 CD19 CD36 CD38 CD53 CD59 CD63 CD81 CLN8 HBEGF IGSF8 ITGA2 ITGA3 ITGA5 ITGB1 KIT PRKCA PTGFRN SERPINH1 TSPAN4 VKORC1
Entrez ID		2515	928
HPRD ID		03322	00880
Ensembl ID		ENSG00000104755	ENSG00000010278
Uniprot IDs		B4DWY7 Q6P2G0 Q99965	A6NNI4 B4DK09 P21926
PDB IDs
Enriched GO Terms of Interacting Partners?
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