DAPK2 and CAMK2A

Number of citations of the paper that reports this interaction (PubMedID 10629061)
41

Data Source:
HPRD (in vitro)

		DAPK2	CAMK2A
Description		death associated protein kinase 2	calcium/calmodulin dependent protein kinase II alpha
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Golgi Apparatus Cytoplasmic Vesicle Autophagosome Lumen Intracellular Membrane-bounded Organelle	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Cell Junction Endocytic Vesicle Membrane Neuron Projection Dendritic Spine
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation Apoptotic Process Regulation Of Autophagy Intracellular Signal Transduction Regulation Of Apoptotic Process Anoikis Protein Autophosphorylation Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Eosinophil Chemotaxis Regulation Of Intrinsic Apoptotic Signaling Pathway	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Angiotensin-activated Signaling Pathway Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Dendritic Spine Development Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Peptidyl-threonine Autophosphorylation Regulation Of Neuron Migration
Pathways		Caspase activation via Dependence Receptors in the absence of ligand	CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants
Drugs			Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}
Diseases
GWAS		Arterial stiffness index ( 31235810) Blood protein levels ( 28240269) Cerebral amyloid deposition (PET imaging) ( 30361487) Cerebrospinal fluid t-tau:AB1-42 ratio ( 28641921) Platelet distribution width ( 27863252) Triglyceride levels ( 31647587) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)	Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Ulcerative colitis ( 28067908)
Interacting Genes		5 interacting genes: APP CAMK2A FAM9B MLC1 TGFBR1	40 interacting genes: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB
Entrez ID		23604	815
HPRD ID		09905	06532
Ensembl ID		ENSG00000035664	ENSG00000070808
Uniprot IDs		A0A024R603 Q9UIK4	A8K161 Q7LDD5 Q8IWE0 Q9UQM7
PDB IDs		1WMK 1WRZ 1Z9X 1ZUZ 1ZWS 2A27 2A2A 2CKE	2VZ6 3SOA 5IG3 6OF8
Enriched GO Terms of Interacting Partners?
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