CAMK2A and GRIN2B

Number of citations of the paper that reports this interaction (PubMedID 11459059)
232

Data Source:
HPRD (in vivo, in vitro)

		CAMK2A	GRIN2B
Description		calcium/calmodulin dependent protein kinase II alpha	glutamate ionotropic receptor NMDA type subunit 2B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Postsynaptic Density Cell Junction Endocytic Vesicle Membrane Neuron Projection Dendritic Spine	Cell Cytoplasm Lysosome Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Postsynaptic Density NMDA Selective Glutamate Receptor Complex Cell Junction Neuron Projection Postsynaptic Membrane Synaptic Membrane Postsynaptic Density Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Calcium-dependent Protein Serine/threonine Kinase Activity Kinase Activity Glutamate Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding	Amyloid-beta Binding NMDA Glutamate Receptor Activity Protein Binding Glutamate Receptor Activity Zinc Ion Binding Ligand-gated Ion Channel Activity Glycine Binding Glutamate Binding Glutamate-gated Calcium Ion Channel Activity Signaling Receptor Activity Transmitter-gated Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Response To Ischemia Protein Phosphorylation Calcium Ion Transport Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Angiotensin-activated Signaling Pathway Protein Autophosphorylation Regulation Of Neurotransmitter Secretion Regulation Of Neuronal Synaptic Plasticity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Calcium Ion Transport Interferon-gamma-mediated Signaling Pathway Dendritic Spine Development Regulation Of Cellular Response To Heat Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Peptidyl-threonine Autophosphorylation Regulation Of Neuron Migration	MAPK Cascade Glutamate Receptor Signaling Pathway Chemical Synaptic Transmission Multicellular Organism Development Brain Development Learning Or Memory Calcium-mediated Signaling Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Response To Ethanol Ephrin Receptor Signaling Pathway Regulation Of Synaptic Plasticity Modulation Of Chemical Synaptic Transmission Protein Heterotetramerization Excitatory Postsynaptic Potential Long-term Synaptic Potentiation Calcium Ion Transmembrane Import Into Cytosol Excitatory Chemical Synaptic Transmission Positive Regulation Of Neuron Death Negative Regulation Of Dendritic Spine Maintenance Regulation Of NMDA Receptor Activity Positive Regulation Of Cysteine-type Endopeptidase Activity
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Ca2+ pathway Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants	EPHB-mediated forward signaling EPHB-mediated forward signaling Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor RAF/MAP kinase cascade Neurexins and neuroligins Synaptic adhesion-like molecules MECP2 regulates neuronal receptors and channels Activated NTRK2 signals through FYN Assembly and cell surface presentation of NMDA receptors Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation
Drugs		Hexatantalum Dodecabromide 1,4-Dithiothreitol (2Z,3E)-2,3'-BIINDOLE-2',3(1H,1'H)-DIONE 3-{O-[(3R)-3,4-DIHYDROXYBUTYL]OXIME}	Glutamic Acid Atomoxetine Pentobarbital Secobarbital Pethidine Haloperidol Acamprosate Felbamate Gabapentin Memantine Phenobarbital Tenocyclidine Prasterone Taurine Milnacipran Acetylcysteine Ketobemidone Gavestinel Ifenprodil Magnesium acetate tetrahydrate Magnesium carbonate Fluciclovine (18F)
Diseases
GWAS		Inflammatory bowel disease ( 28067908) Obesity-related traits ( 23251661) Ulcerative colitis ( 28067908)	Adventurousness ( 30643258) Aging (time to event) ( 21782286) Alzheimer's disease in hypertension ( 31055733) Brain structure (temporal lobe volume) ( 20197096) Cellular nuclear factor (erythroid-derived 2)-like 2 levels ( 30767168) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Cognitive performance ( 19734545) Egg allergy (parent-of-origin effect) ( 29489655) General risk tolerance (MTAG) ( 30643258) Height ( 31562340) Immune reponse to smallpox (secreted IL-2) ( 22610502) Major depressive disorder ( 23377640) Ovarian reserve ( 22116950) Response to selective serotonin reuptake inhibitors in depression ( 30034349) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Systolic blood pressure ( 30224653) Total ventricular volume ( 21116278) Waist-hip ratio ( 28552196) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		40 interacting genes: ACTN1 ACTN2 ACTN4 ATF1 ATP2A2 CAMK2N2 CDK5R1 CDK5R2 CEBPB CHAT CREB1 DAPK2 DLG1 EGFR ETS1 GFAP GRIN1 GRIN2A GRIN2B HSF1 ITGA2B ITGB1BP1 ITPKA KRT18 LRRC7 MAPT MPDZ NOS1 PDC PPM1F PSMC5 PTTG1 RCHY1 RIMS1 SMAD2 SQSTM1 SRF SYNGAP1 TANC1 YWHAB	40 interacting genes: ACTN2 AP1M1 AP2M1 AP4M1 ARHGAP32 CAMK2A CAMK2B CAMK2D CAMK2G CAMK2N1 CAPN1 DLG1 DLG2 DLG3 DLG4 EPHB2 ERBIN EXOC4 EXOC7 FYN GRIN1 GRIN3A IL16 LIN7A LIN7B MAGI3 MIB2 PATJ PIK3CA PLCG1 PRKCA PRKCB PRKCG PRKN PTPN11 RACK1 SPTAN1 SRC SYNGAP1 TANC1
Entrez ID		815	2904
HPRD ID		06532	00697
Ensembl ID		ENSG00000070808	ENSG00000273079
Uniprot IDs		A8K161 Q7LDD5 Q8IWE0 Q9UQM7	Q13224
PDB IDs		2VZ6 3SOA 5IG3 6OF8	1S11 1S2S 2IPV 5EWJ 5EWL 5EWM
Enriched GO Terms of Interacting Partners?
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