ORC6 and ORC2

Number of citations of the paper that reports this interaction (PubMedID 11323433)
57

Data Source:
HPRD (in vivo, in vitro)

		ORC6	ORC2
Description		origin recognition complex subunit 6	origin recognition complex subunit 2
Image
GO Annotations	Cellular Component	Origin Recognition Complex Fibrillar Center Nucleoplasm Nuclear Origin Of Replication Recognition Complex Membrane	Nuclear Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane
	Molecular Function	DNA Binding Protein Binding	DNA Replication Origin Binding Protein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle DNA Replication DNA Replication Initiation Negative Regulation Of Cell Division	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS			Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)
Interacting Genes		19 interacting genes: APP CDC45 CDC6 CDC7 DBF4 HMGA1 LHX4 MCM2 MCM4 MCM5 MCM6 MCM7 ORC2 ORC3 ORC4 ORC5 RPA1 SPAG5 TERF2	26 interacting genes: BCS1L CDC45 CDC5L CDC6 CDK2 CDT1 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 XRCC5
Entrez ID		23594	4999
HPRD ID		06237	03112
Ensembl ID		ENSG00000091651	ENSG00000115942
Uniprot IDs		A0A024R6R3 Q9Y5N6	A0A024R411 Q13416
PDB IDs		3M03	5C8H 5UJ8 5UJM
Enriched GO Terms of Interacting Partners?
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