ORC2 and BCS1L

		ORC2	BCS1L
Description		origin recognition complex subunit 2	BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Heterochromatin Origin Recognition Complex Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Centrosome Membrane	Mitochondrion Mitochondrial Respiratory Chain Complex III Integral Component Of Membrane
	Molecular Function	DNA Replication Origin Binding Protein Binding	Protein Binding ATP Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II DNA Replication DNA Replication Initiation	Mitochondrion Organization Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Respiratory Chain Complex IV Assembly Mitochondrial Respiratory Chain Complex III Assembly
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Assembly of the ORC complex at the origin of replication CDC6 association with the ORC:origin complex CDT1 association with the CDC6:ORC:origin complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex	Mitochondrial protein import
Drugs
Diseases			Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Plasma parathyroid hormone levels ( 30134803) Triptolide cytotoxicity ( 26121980)	Male-pattern baldness ( 28196072)
Interacting Genes		26 interacting genes: BCS1L CDC45 CDC5L CDC6 CDK2 CDT1 DBF4 EP300 H3-4 H4-16 KAT7 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 ORC1 ORC3 ORC4 ORC5 ORC6 RPA1 RPA2 XRCC5	14 interacting genes: AOX1 ARHGAP18 CD28 CLK1 CTLA4 DDX24 DNAJA1 MRPS12 MTDH ORC2 RP9 RPE SLC29A1 WDFY1
Entrez ID		4999	617
HPRD ID		03112	04708
Ensembl ID		ENSG00000115942	ENSG00000074582
Uniprot IDs		A0A024R411 Q13416	A0A024R445 A8JZZ8 Q9Y276
PDB IDs		5C8H 5UJ8 5UJM
Enriched GO Terms of Interacting Partners?
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