RHOQ and PARD6B

Number of citations of the paper that reports this interaction (PubMedID 10934474)
300

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		RHOQ	PARD6B
Description		ras homolog family member Q	par-6 family cell polarity regulator beta
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Actin Filament Plasma Membrane Cell Cortex Golgi-associated Vesicle Membrane Cytoplasmic Vesicle Cell Projection Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome	Nucleus Cytosol Plasma Membrane Bicellular Tight Junction Cell Cortex Apical Plasma Membrane Protein-containing Complex Extracellular Exosome
	Molecular Function	GTPase Activity Profilin Binding GTP Binding Protein Kinase Binding GBD Domain Binding	Protein Kinase C Binding Protein Binding Rho GTPase Binding
	Biological Process	Endocytosis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Insulin Receptor Signaling Pathway Regulation Of Cell Shape Cell Migration Cell Projection Assembly Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Cellular Response To Insulin Stimulus Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Transcription By RNA Polymerase II GTP Metabolic Process Positive Regulation Of Glucose Import Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Filopodium Assembly Negative Regulation Of Protein Localization To Plasma Membrane	Cell-cell Junction Assembly Centrosome Cycle Establishment Or Maintenance Of Cell Polarity Axonogenesis Regulation Of Cell Migration Cell Division Regulation Of Cellular Localization Protein-containing Complex Assembly Bicellular Tight Junction Assembly
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Rho GTPase cycle RHO GTPases regulate CFTR trafficking	Tight junction interactions
Drugs
Diseases
GWAS			Bipolar disorder ( 21771265)
Interacting Genes		18 interacting genes: CDC42BPG CDC42EP1 CDC42EP2 CDC42EP3 CDC42EP4 COPB1 COPG1 DOCK8 EXOC7 GOPC PARD6A PARD6B PFN1 PRKCI RAPGEF1 TRIP10 TRIP6 WASL	24 interacting genes: APP ARAP3 CDC42 CEP76 GMCL1 GOLGA2 HTRA1 MPP5 PARD3 PARD3B PARD6A PNMA1 PRKCG PRKCI PRKCZ RAC1 RHOJ RHOQ SIAH1 TCP10L3 WDR83 YWHAB YWHAH YWHAZ
Entrez ID		23433	84612
HPRD ID		05791	18703
Ensembl ID		ENSG00000119729	ENSG00000124171
Uniprot IDs		D6W5A7 P17081 V9HWD0	Q9BYG5
PDB IDs		2ATX
Enriched GO Terms of Interacting Partners?
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