RHOBTB2 and BAG4

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		RHOBTB2	BAG4
Description		Rho related BTB domain containing 2	BAG cochaperone 4
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell Cortex Cytoplasmic Vesicle Cell Division Site Intracellular Membrane-bounded Organelle	Nucleus Cytosol Plasma Membrane
	Molecular Function	GTPase Activity Protein Binding GTP Binding Protein Kinase Binding	RNA Binding Protein Binding Ubiquitin Protein Ligase Binding Chaperone Binding
	Biological Process	Cytokinesis Actin Filament Organization Establishment Or Maintenance Of Cell Polarity Rho Protein Signal Transduction Regulation Of Cell Shape Regulation Of Cell Migration Establishment Or Maintenance Of Actin Cytoskeleton Polarity Regulation Of Actin Cytoskeleton Organization Actin Filament Bundle Assembly Regulation Of Small GTPase Mediated Signal Transduction	Protein Folding Positive Regulation Of Fibroblast Migration Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Protein Kinase B Signaling Cellular Response To Tumor Necrosis Factor Cellular Response To Epidermal Growth Factor Stimulus Protein Localization To Plasma Membrane Ruffle Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Protein Targeting To Mitochondrion Negative Regulation Of Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase Activity
Pathways		Rho GTPase cycle	Regulation of HSF1-mediated heat shock response Signaling by FGFR1 in disease TNF signaling Signaling by plasma membrane FGFR1 fusions
Drugs
Diseases
GWAS		Alzheimer's disease progression score ( 29860282) Height ( 28552196) Plasma trimethylamine N-oxide levels ( 28439531) Renal cell carcinoma ( 28598434) Survival in breast cancer (estrogen-receptor positive) ( 29423119)	Autism spectrum disorder or schizophrenia ( 28540026) Schizophrenia ( 28991256 29483656)
Interacting Genes		12 interacting genes: BAG4 CHEK2 CUL5 ERBB2 FGFR2 HSP90AA1 HSP90AB1 PALB2 PPM1D PTPN1 RHOBTB3 STK11	38 interacting genes: APOBEC1 ATAD2 BAP1 BCAS3 BCL2 BEX1 CASZ1 CCL5 DIRAS3 EPSTI1 ERRFI1 GLCE GRAP2 HSPA1A HSPA8 IL13RA2 IL24 ITIH5 KLK5 KLK7 KLK9 LRATD2 LYPD3 MRC2 MTA3 NAT2 PDLIM2 PLAT PRDM14 RASL10B RHOBTB2 RNF20 RPL22 SCGB3A1 TBC1D7 THRSP TNFRSF1A TNFRSF25
Entrez ID		23221	9530
HPRD ID		06300	04861
Ensembl ID		ENSG00000008853	ENSG00000156735
Uniprot IDs		Q9BYZ6	O95429
PDB IDs			1M62 1M7K
Enriched GO Terms of Interacting Partners?
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