TNRC6B and CNOT1

Number of citations of the paper that reports this interaction (PubMedID 21981923)
144

Data Source:
BioGRID (pull down)

		TNRC6B	CNOT1
Description		trinucleotide repeat containing adaptor 6B	CCR4-NOT transcription complex subunit 1
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleoplasm Cytosol	P-body Extracellular Space Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex
	Molecular Function	RNA Binding Protein Binding	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding
	Biological Process	Wnt Signaling Pathway, Calcium Modulating Pathway Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Gene Silencing By RNA Posttranscriptional Gene Silencing By RNA Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Multicellular Organism Development Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance
Pathways		Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Bitter alcoholic beverage consumption ( 31046077) Body mass index ( 28892062 25673413) Breast size ( 29855537) Chronotype ( 26955885 30696823) Diastolic blood pressure ( 30578418) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31015462) Hand grip strength ( 25637336) Height ( 19570815) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mammographic density (dense area) ( 25342443) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Morning person ( 30696823) Neutrophil percentage of white cells ( 27863252) Prostate cancer ( 23065704 19117981) Pulse pressure ( 27841878 27618447 30578418) Regular attendance at a pub or social club ( 29970889) Systolic blood pressure ( 27618447) Uterine fibroids ( 21460842 31249589 30194396 31649266)	Autism spectrum disorder or schizophrenia ( 28540026) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 22726844 19305408) Schizophrenia ( 25056061 29483656 30285260)
Interacting Genes		4 interacting genes: AGO4 CNOT1 PAN3 UBQLN4	12 interacting genes: CNOT2 CNOT3 CNOT4 CNOT8 CNOT9 DDX6 NANOS3 PPARG RARA RXRA THRB TNRC6B
Entrez ID		23112	23019
HPRD ID		10021	11999
Ensembl ID		ENSG00000100354	ENSG00000125107
Uniprot IDs		A0A024R1N5 Q9UPQ9	A5YKK6
PDB IDs			4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA
Enriched GO Terms of Interacting Partners?
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