CNOT1 and NANOS3

Number of citations of the paper that reports this interaction (PubMedID 24736845)
36

Data Source:
BioGRID (pull down)

		CNOT1	NANOS3
Description		CCR4-NOT transcription complex subunit 1	nanos C2HC-type zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	P-body Extracellular Space Nucleus Cytosol Membrane CCR4-NOT Complex CCR4-NOT Core Complex	P-body Nucleus Cytoplasm Cytoplasmic Stress Granule Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Poly(A)-specific Ribonuclease Activity Protein Binding Protein Domain Specific Binding Estrogen Receptor Binding Retinoic Acid Receptor Binding Molecular Adaptor Activity Armadillo Repeat Domain Binding	RNA Binding Protein Binding Zinc Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Poly(A) Tail Shortening DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Multicellular Organism Development Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly Negative Regulation Of Translation Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Gene Silencing By MiRNA Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of MRNA Catabolic Process RNA Phosphodiester Bond Hydrolysis, Exonucleolytic Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Regulation Of Stem Cell Population Maintenance	Regulation Of Translation Multicellular Organism Development Germ Cell Development Spermatogenesis Negative Regulation Of Translation Oogenesis Regulation Of Cell Cycle Positive Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Negative Regulation Of Apoptotic Signaling Pathway
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Pulse pressure ( 30224653) QT interval ( 30679814 24952745 22726844 19305408) Schizophrenia ( 25056061 29483656 30285260)	Hand grip strength ( 29691431)
Interacting Genes		12 interacting genes: CNOT2 CNOT3 CNOT4 CNOT8 CNOT9 DDX6 NANOS3 PPARG RARA RXRA THRB TNRC6B	2 interacting genes: CNOT1 SIAH1
Entrez ID		23019	342977
HPRD ID		11999	19428
Ensembl ID		ENSG00000125107	ENSG00000187556
Uniprot IDs		A5YKK6	P60323
PDB IDs		4C0D 4CQO 4CRU 4CRV 4CRW 4CT4 4CT6 4CT7 4GMJ 4GML 4J8S 5ANR 5FU6 5FU7 5ONA
Enriched GO Terms of Interacting Partners?
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