CDK19 and PRMT5

Number of citations of the paper that reports this interaction (PubMedID 23749998)
30

Data Source:
BioGRID (pull down)

		CDK19	PRMT5
Description		cyclin dependent kinase 19	protein arginine methyltransferase 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Mediator Complex	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Methylosome Histone Methyltransferase Complex
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Activity ATP Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity	P53 Binding Transcription Corepressor Activity Protein Binding Methyltransferase Activity Methyl-CpG Binding Histone-arginine N-methyltransferase Activity Protein-arginine N-methyltransferase Activity Protein-arginine Omega-N Symmetric Methyltransferase Activity Identical Protein Binding Ribonucleoprotein Complex Binding Histone Methyltransferase Activity (H4-R3 Specific) Protein Heterodimerization Activity E-box Binding
	Biological Process	Protein Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of Inflammatory Response Regulation Of Cell Cycle Cellular Response To Lipopolysaccharide	Spliceosomal SnRNP Assembly DNA-templated Transcription, Termination Regulation Of Transcription, DNA-templated Regulation Of Mitotic Nuclear Division Peptidyl-arginine Methylation Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Circadian Regulation Of Gene Expression Histone Arginine Methylation Peptidyl-arginine N-methylation Endothelial Cell Activation Histone H4-R3 Methylation Regulation Of DNA Methylation Negative Regulation Of Cell Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of ERK1 And ERK2 Cascade Golgi Ribbon Formation Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Adenylate Cyclase-inhibiting Dopamine Receptor Signaling Pathway
Pathways		PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	snRNP Assembly RMTs methylate histone arginines Regulation of TP53 Activity through Methylation
Drugs
Diseases
GWAS		General risk tolerance (MTAG) ( 30643258) Zinc levels ( 26025379)	Cortical amyloid beta load ( 29860282) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993)
Interacting Genes		8 interacting genes: BCL6 EIF3F PRMT5 SMARCA4 SRSF7 SUZ12 USP54 WDR77	79 interacting genes: ARGLU1 CALU CAPN1 CCAR2 CDK19 CDK8 CDYL2 CLK1 CLK3 CLNS1A CTDP1 DIO3 DNMT3A DUSP14 EZH2 FAM76B GLI1 GRHL3 GTPBP2 H2AC20 H3-4 H3-5 H3C1 H4-16 H4C1 HOXC4 ILF3 ING5 JAK1 JAK2 JAK3 LDHAL6B LENG8 LUC7L MAGEB2 MBP MCRS1 MEF2D MYOD1 MYOG NCL NELFCD NUDCD2 OLA1 PDGFRA PHYHIP POLR2A PRPF38A RBM23 RSRP1 SF3A3 SIN3A SLU7 SMARCA2 SMARCB1 SMARCC1 SMARCE1 SNRNP70 SNRPB SNRPD1 SNRPD3 SPAG8 SREBF1 SSTR1 STUB1 SUPT5H TRIB3 TYK2 UBE3A WDR5 WDR77 YWHAG YWHAQ YWHAZ ZDHHC17 ZNF2 ZNF224 ZNF436 ZUP1
Entrez ID		23097	10419
HPRD ID		07627	04955
Ensembl ID		ENSG00000155111	ENSG00000100462
Uniprot IDs		B4DUB1 I6W807 Q9BWU1	B4DV00 O14744
PDB IDs			4GQB 4X60 4X61 4X63 5C9Z 5EMJ 5EMK 5EML 5EMM 5FA5 6CKC 6K1S
Enriched GO Terms of Interacting Partners?
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