FOXO3 and IKBKB

Number of citations of the paper that reports this interaction (PubMedID 15084260)
319

Data Source:
BioGRID (imaging technique)
HPRD (in vivo, in vitro)

		FOXO3	IKBKB
Description		forkhead box O3	inhibitor of nuclear factor kappa B kinase subunit beta
Image
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Matrix Cytosol Protein-containing Complex	Nucleus Cytoplasm Cytosol IkappaB Kinase Complex Cytoplasmic Side Of Plasma Membrane CD40 Receptor Complex Membrane Raft
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Cofactor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Protein Kinase Binding Chromatin DNA Binding Mitochondrial Sequence-specific DNA-binding Transcription Factor Activity Sequence-specific DNA Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding IkappaB Kinase Activity Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Scaffold Protein Binding Transferrin Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Ovulation From Ovarian Follicle Initiation Of Primordial Ovarian Follicle Growth Antral Ovarian Follicle Growth Oocyte Maturation Regulation Of Transcription By RNA Polymerase II Mitochondrial Transcription Regulation Of Translation Aging Insulin Receptor Signaling Pathway Positive Regulation Of Autophagy Positive Regulation Of Muscle Atrophy Cytokine-mediated Signaling Pathway DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Cell Migration Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Oxidative Stress Glucose Homeostasis Response To Starvation Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Brain Morphogenesis Cellular Response To Glucose Stimulus Cellular Response To Corticosterone Stimulus Cellular Response To Hypoxia Response To Dexamethasone Negative Regulation Of Canonical Wnt Signaling Pathway Neuronal Stem Cell Population Maintenance Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Cellular Response To Nerve Growth Factor Stimulus Response To Water-immersion Restraint Stress Regulation Of Neural Precursor Cell Proliferation Positive Regulation Of Endothelial Cell Apoptotic Process	Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent MyD88-independent Toll-like Receptor Signaling Pathway Protein Phosphorylation Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Response To Virus Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Viral Process Peptidyl-serine Phosphorylation Cortical Actin Cytoskeleton Organization Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Myosin-light-chain-phosphatase Activity TRIF-dependent Toll-like Receptor Signaling Pathway Fc-epsilon Receptor Signaling Pathway Regulation Of Phosphorylation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Protein Localization To Plasma Membrane Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Bicellular Tight Junction Assembly
Pathways		Signaling by NODAL AKT phosphorylates targets in the nucleus Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models RUNX3 regulates BCL2L11 (BIM) transcription Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling	Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells ER-Phagosome pathway NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment RIP-mediated NFkB activation via ZBP1 Downstream TCR signaling p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway IKBKB deficiency causes SCID IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR) IkBA variant leads to EDA-ID CLEC7A (Dectin-1) signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Interleukin-1 signaling TRAF6 mediated NF-kB activation NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Drugs			Mesalazine Sulfasalazine Acetylsalicylic acid Auranofin Arsenic trioxide MLN0415 Acetylcysteine
Diseases
GWAS		Anxiety/tension (special factor of neuroticism) ( 30867560) Blood protein levels in cardiovascular risk ( 28369058) BMI (adjusted for smoking behaviour) ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Estimated glomerular filtration rate ( 31152163) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 31562340) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Insulin-like growth factors ( 21216879) Intelligence ( 28530673) Intelligence (MTAG) ( 29326435) Lead levels ( 26025379) Macular thickness ( 30535121) Normalized brain volume ( 19010793) Platelet distribution width ( 27863252) Poor prognosis in Crohn's disease ( 28067912) Prostate cancer ( 23535732) Pulse pressure ( 30224653) Reaction time ( 29844566) Reticulocyte fraction of red cells ( 27863252) Schizophrenia ( 28991256 30285260) Smoking status (ever vs never smokers) ( 30643258) Vigorous physical activity ( 29899525) Waist circumference ( 25673412) Weight ( 28552196)
Interacting Genes		27 interacting genes: AKT1 ATM BTRC CDK6 CDT1 CHUK EP300 ERBIN ESR1 FOXG1 HDAC2 IKBKB MAPK1 MAPK6 NR1H2 NR1H3 PTPA SGK1 SIRT1 SMAD2 SMAD3 SMAD4 TERT TP53 VDR YWHAG YWHAZ	86 interacting genes: ACVR1 AKT1 AURKA CASP8 CCAR2 CDC37 CFLAR CHUK COPS3 COPS4 CSF2RA CSF2RB CTNNB1 CUEDC2 E2F4 EIF2AK2 EIF2AK3 ELP1 FAF1 FANCA FOXO3 GLI1 HSP90AA1 HSP90AB1 HTT IKBKG IRS1 JUN KLHL21 MAP3K1 MAP3K11 MAP3K13 MAP3K14 MAP3K3 MAP3K7 MAVS MTDH NAA20 NCOA3 NEDD4L NFKB1 NFKB2 NFKBIA NFKBIB NR2C2 PEBP1 PELI1 PLK1 PPARG PPM1B PPP2R3C PRKCA PRKCB PRKCD PRKCE PRKCQ PRKCZ PRKDC RELA RICTOR RIPK1 ROCK1 SASH1 SRC STAP2 TAB2 TANK TBK1 TFAP2C TGFBR1 TNFAIP3 TNFRSF1A TP53 TP73 TRAF1 TRAF2 TRAF3IP2 TRIM21 TRIM27 TRPC4AP TSC1 TWIST1 UBB UBC VHL YWHAB
Entrez ID		2309	3551
HPRD ID		04061	04462
Ensembl ID		ENSG00000118689	ENSG00000104365
Uniprot IDs		O43524	O14920
PDB IDs		2K86 2LQH 2LQI 2UZK 6MNL	3BRT 3BRV 4E3C 4KIK
Enriched GO Terms of Interacting Partners?
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