FOXO1 and HNF4A

Number of citations of the paper that reports this interaction (PubMedID 12519792)
32

Data Source:
HPRD (in vitro)

		FOXO1	HNF4A
Description		forkhead box O1	hepatocyte nuclear factor 4 alpha
Image
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Activating Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Signaling Receptor Binding Fatty Acid Binding Protein Binding Zinc Ion Binding Protein Homodimerization Activity Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Temperature Homeostasis Cellular Glucose Homeostasis Protein Acetylation Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Insulin Receptor Signaling Pathway Cellular Response To Starvation Positive Regulation Of Autophagy Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Enamel Mineralization Cellular Response To Hydrogen Peroxide Cellular Response To Cold Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Energy Homeostasis Neuronal Stem Cell Population Maintenance Response To Fluoride Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process	Type B Pancreatic Cell Development Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Ornithine Metabolic Process Lipid Metabolic Process Xenobiotic Metabolic Process Sex Differentiation Blood Coagulation Negative Regulation Of Cell Proliferation Response To Glucose Regulation Of Gastrulation Regulation Of Lipid Metabolic Process Signal Transduction Involved In Regulation Of Gene Expression Cell Differentiation Negative Regulation Of Cell Growth Glucose Homeostasis Cholesterol Homeostasis Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Anatomical Structure Development Regulation Of Insulin Secretion Lipid Homeostasis Phospholipid Homeostasis SMAD Protein Signal Transduction Triglyceride Homeostasis Hepatocyte Differentiation
Pathways		AKT phosphorylates targets in the nucleus Regulation of gene expression in beta cells AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes	Nuclear Receptor transcription pathway
Drugs			Lauric Acid AVI-4557 Myristic acid
Diseases		Alveolar rhabdomyosarcoma	Maturity onset diabetes of the young (MODY)
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Central corneal thickness ( 20485516 31798171 29760442 20719862) Corneal hysteresis ( 31246245 30894546) Corneal resistance factor ( 31246245 30894546) Corneal structure ( 23291589) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 29235454) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Red blood cell count ( 29403010) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 30194396 31649266) Weight ( 28552196)	C-reactive protein ( 22939635) C-reactive protein levels ( 30388399 21300955) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 20686565) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Coenzyme Q10 levels ( 27149984) Estimated glomerular filtration rate ( 31152163) Factor VII activity ( 30642921) Fibrinogen levels ( 28107422 26561523) Gallstone disease ( 30504769) Granulocyte count ( 27863252) HDL cholesterol ( 24097068 19060906 30275531 25961943 20686565) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematocrit ( 27863252) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Medication use (drugs used in diabetes) ( 31015401) Metabolic syndrome ( 31589552) Myeloid white cell count ( 27863252) Neutrophil count ( 27863252) Neutrophil percentage of white cells ( 27863252) Pancreatic cancer ( 29422604) Serum uric acid levels ( 30993211) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 24509480 30054458 21874001 30297969 29632382 31118516 22158537 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Ulcerative colitis ( 19915572 23128233) Urate levels ( 31578528)
Interacting Genes		37 interacting genes: AKT1 AR BCKDK CEBPB CREBBP CSNK1G1 CTNNB1 DACH1 DYRK1A ESR1 FHL2 FOXG1 G6PC GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 NCOA1 PAK1 PARP1 PIK3R3 PITX1 PPARG RARA SET SFN SIRT1 SMAD3 SMAD4 SRC THRB TNS2 YWHAG YWHAZ	68 interacting genes: ANP32B ARNT COPS5 CREBBP DMD EIF1AY ESR1 FOXO1 GTF2B GTF2H1 HDAC3 HDAC4 HIF1A HNF1A ISL1 MAPK1 MAPK14 MAPK3 MECR MED1 MED10 MED14 MED16 MED17 MED21 MED24 MED7 NCOA1 NCOA2 NCOA6 NCOR2 NPPA NR0B2 NR1I2 NR1I3 NR2C2 NR2F1 NRBF2 NRIP1 PCBD1 PIAS4 PLPP2 PNRC1 PNRC2 PPARGC1A PPARGC1B PRKAA2 PRKACA PRMT1 PROX1 RNF4 SIRT1 SMAD2 SMAD3 SMAD4 SP1 SREBF1 SREBF2 SUB1 TAF6 TAF9 TBP TGS1 TP53 TRIM24 UBE2I XPO1 ZNHIT3
Entrez ID		2308	3172
HPRD ID		00645	02612
Ensembl ID		ENSG00000150907	ENSG00000101076
Uniprot IDs		Q12778	A0A087WXV4 B9VVT8 F1D8S2 F1D8T0 F1D8T1 P41235
PDB IDs		3CO6 3CO7 3COA 4LG0 5DUI 6QVW 6QZR 6QZS	1PZL 3CBB 3FS1 4B7W 4IQR 6CHT
Enriched GO Terms of Interacting Partners?
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