FOXO1 and FOXG1

Number of citations of the paper that reports this interaction (PubMedID 15084259)
324

Data Source:
HPRD (in vivo)

		FOXO1	FOXG1
Description		forkhead box O1	forkhead box G1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol	Nuclear Chromatin Nucleoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Transcription Factor Binding Ubiquitin Protein Ligase Binding Sequence-specific DNA Binding Protein Phosphatase 2A Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Sequence-specific DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Blood Vessel Development Temperature Homeostasis Cellular Glucose Homeostasis Protein Acetylation Autophagy Apoptotic Process Cellular Response To DNA Damage Stimulus Insulin Receptor Signaling Pathway Cellular Response To Starvation Positive Regulation Of Autophagy Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Cellular Response To Insulin Stimulus Negative Regulation Of Stress-activated MAPK Cascade Cellular Response To Oxidative Stress Glucose Homeostasis Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Fat Cell Differentiation Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Gluconeogenesis Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Enamel Mineralization Cellular Response To Hydrogen Peroxide Cellular Response To Cold Cellular Response To Hyperoxia Cellular Response To Dexamethasone Stimulus Cellular Response To Nitric Oxide Negative Regulation Of Canonical Wnt Signaling Pathway Energy Homeostasis Neuronal Stem Cell Population Maintenance Response To Fluoride Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Regulation Of Neural Precursor Cell Proliferation Regulation Of Reactive Oxygen Species Metabolic Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Neuroblast Proliferation Regulation Of Mitotic Cell Cycle Brain Development Aging Dorsal/ventral Pattern Formation Axon Midline Choice Point Recognition Pyramidal Neuron Migration Inner Ear Morphogenesis Negative Regulation Of Neuron Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Neuron Fate Determination
Pathways		AKT phosphorylates targets in the nucleus Regulation of gene expression in beta cells AKT-mediated inactivation of FOXO1A Constitutive Signaling by AKT1 E17K in Cancer MAPK6/MAPK4 signaling Interleukin-4 and Interleukin-13 signaling Regulation of localization of FOXO transcription factors FOXO-mediated transcription of cell death genes FOXO-mediated transcription of cell death genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes Regulation of FOXO transcriptional activity by acetylation Regulation of FOXO transcriptional activity by acetylation FOXO-mediated transcription of cell cycle genes FOXO-mediated transcription of cell cycle genes	Regulation of MECP2 expression and activity FOXO-mediated transcription of cell cycle genes
Drugs
Diseases		Alveolar rhabdomyosarcoma	Rett syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Arterial stiffness ( 31070453) Arterial stiffness index ( 31235810) Central corneal thickness ( 20485516 31798171 29760442 20719862) Corneal hysteresis ( 31246245 30894546) Corneal resistance factor ( 31246245 30894546) Corneal structure ( 23291589) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998 29235454) Mean corpuscular hemoglobin ( 29403010 27863252) Mean corpuscular volume ( 29403010 27863252) Metabolite levels ( 23823483) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Red blood cell count ( 29403010) Sum eosinophil basophil counts ( 27863252) Uterine fibroids ( 30194396 31649266) Weight ( 28552196)	Longevity ( 20834067) Manganese levels ( 26025379) Metabolite levels ( 23823483) Number of sexual partners ( 30643258) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Resting oxygen saturation in chronic osbtructive pulmonary disease (pulse oxymetry) ( 24825563) Smoking status (ever vs never smokers) ( 30643258) Takayasu arteritis ( 25604533)
Interacting Genes		37 interacting genes: AKT1 AR BCKDK CEBPB CREBBP CSNK1G1 CTNNB1 DACH1 DYRK1A ESR1 FHL2 FOXG1 G6PC GSK3B HNF4A HOXA10 HOXA5 LRPPRC MDM2 MST1 NCOA1 PAK1 PARP1 PIK3R3 PITX1 PPARG RARA SET SFN SIRT1 SMAD3 SMAD4 SRC THRB TNS2 YWHAG YWHAZ	19 interacting genes: APOE AR EEF1G FOXH1 FOXO1 FOXO3 FOXO4 GDF9 HDAC1 HES1 KDM5B SMAD1 SMAD2 SMAD3 SMAD4 SRF TLE1 TLE3 TLE6
Entrez ID		2308	2290
HPRD ID		00645	01283
Ensembl ID		ENSG00000150907	ENSG00000176165
Uniprot IDs		Q12778	P55316
PDB IDs		3CO6 3CO7 3COA 4LG0 5DUI 6QVW 6QZR 6QZS
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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