NT5C2 and SDCBP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NT5C2	SDCBP
Description		5'-nucleotidase, cytosolic II	syndecan binding protein
Image
GO Annotations	Cellular Component	Cytosol	Extracellular Region Extracellular Space Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Membrane Cytosol Cytoskeleton Plasma Membrane Interleukin-5 Receptor Complex Adherens Junction Focal Adhesion Membrane Nuclear Membrane Azurophil Granule Lumen Melanosome Membrane Raft Synapse Extracellular Exosome Blood Microparticle Extracellular Vesicle
	Molecular Function	Nucleotide Binding Protein Binding 5'-nucleotidase Activity Metal Ion Binding	Frizzled Binding Interleukin-5 Receptor Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Cytoskeletal Adaptor Activity Identical Protein Binding Syndecan Binding Protein Heterodimerization Activity Protein N-terminus Binding
	Biological Process	Purine Nucleotide Catabolic Process Dephosphorylation Drug Metabolic Process IMP Metabolic Process Adenosine Metabolic Process	Negative Regulation Of Receptor Internalization Protein Targeting To Membrane Substrate-dependent Cell Migration, Cell Extension Chemical Synaptic Transmission Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Proliferation Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Actin Cytoskeleton Organization Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Positive Regulation Of Phosphorylation Neutrophil Degranulation Positive Regulation Of JNK Cascade Ephrin Receptor Signaling Pathway Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly
Pathways		Abacavir metabolism Purine catabolism	Ephrin signaling Neurofascin interactions Neutrophil degranulation
Drugs		ATP Ribavirin
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Birth weight ( 31043758 27680694) Blood pressure ( 21572416 24001895 21909110) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 24861553 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronotype ( 30696823) Coronary artery disease ( 24262325 26343387) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary artery disease or large artery stroke ( 24262325) Coronary heart disease ( 21378990) Diastolic blood pressure ( 28739976 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hypertension ( 31879980 30487518) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Mean arterial pressure ( 26390057 29403010 27618448 30487518) Myocardial infarction ( 26343387) Pulse pressure ( 29403010 28739976 30487518 30578418) Red cell distribution width ( 27863252) Response to citalopram or escitalopram and depression ( 27622933) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309) Reticulocyte fraction of red cells ( 27863252) Schizophrenia ( 28991256 25056061 21926974 29483656 22688191 30285260 23974872 23894747) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 26390057 28135244 19430483 21909115 29403010 28739976 27618447 27618452 30487518) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure (long-term average) ( 28348047) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) White matter lesion progression ( 26451028)
Interacting Genes		10 interacting genes: ATP5PO CALM1 FXR2 MOB1B MOB3B MOB3C NME7 NOC4L NUDT18 SDCBP	173 interacting genes: ABI2 ANKRD40 ANP32B APIP BCL2L15 C11orf68 C1orf109 CADM1 CADPS CALCOCO2 CBR3 CBY2 CCDC102B CD6 CD63 CDA CDC34 CDCP1 CDIPT CEP55 CGGBP1 CLK2 CLK3 CMTM5 COX4I1 CRYAA CT45A3 CT45A5 CUTC DCTD DCTPP1 DMC1 DRAP1 DTNBP1 EAF1 EDARADD EFNB1 EFNB2 EIF1AD EIF5A2 ELAVL1 ENOX1 ENTR1 EPHB2 ERICH2 FAM118A FAM118B FAM9B FLAD1 FOXP2 FTH1 FTL GNMT GPATCH11 GPR37 GRIA1 GRIA2 GRIA3 GRIA4 GRIK1 GRIK2 GRM2 GRM3 GRM7 HIVEP1 HMGB3 HNRNPC HOMEZ HOXA1 HPRT1 HSBP1 IHO1 IKZF1 IL5RA INO80E KCNH1 KCTD1 KCTD6 KCTD9 KHDRBS2 KLHL12 KLHL2 KRTAP10-3 KRTAP10-7 KRTAP5-9 LDOC1 LGALS2 LSM6 LZTFL1 MAD2L1 MAPRE3 MBD3 MED4 MID2 MRFAP1L1 MTUS2 NADK NAGK NECAB2 NF2 NFASC NKAPD1 NOTCH2NLA NT5C2 OSTF1 PDCD6IP PDE4DIP PHC2 PNMA1 PNMA2 PRPF38A PRPF40A PRR13 PSMC6 PSTPIP1 PTEN PTPRJ PTS PUF60 PYCR3 RAB5A RBM39 REEP6 REL RIC8A RNF11 RNH1 ROPN1 RP9P RPL22 RTN1 RUNDC3A SDC1 SDC2 SDC4 SDCBP2 SEPTIN3 SET SIAH1 SLC6A5 SMARCA2 SOX4 SREK1IP1 SRSF11 SRSF7 SSNA1 STX1A SULT1B1 TDO2 TEKT1 TFCP2 TGFA THG1L TIFA TKFC TLE5 TMEM239 TNFAIP8 TRAF5 TRIM27 TRIM32 TRIM38 TRIM54 UBC UBE2A ULK1 WASHC3 WASL WDR91 ZBTB14 ZBTB8A ZCCHC10 ZCCHC17
Entrez ID		22978	6386
HPRD ID		02686	03741
Ensembl ID		ENSG00000076685	ENSG00000137575
Uniprot IDs		A0A384MED8 A8K6K2 P49902	A0A024R7Z5 B4DHN5 G5EA09 O00560
PDB IDs		2J2C 2JC9 2JCM 2XCV 2XCW 2XCX 2XJB 2XJC 2XJD 2XJE 2XJF 4H4B 5CQZ 5CR7 5K7Y 5L4Z 5L50 5OPK 5OPL 5OPM 5OPN 5OPO 5OPP 6DD3 6DDB 6DDC 6DDH 6DDK 6DDL 6DDO 6DDQ 6DDX 6DDY 6DDZ 6DE0 6DE1 6DE2 6DE3 6FIR 6FIS 6FIU 6FIW 6FXH	1N99 1NTE 1OBX 1OBY 1OBZ 1R6J 1V1T 1W9E 1W9O 1W9Q 1YBO 4Z33
Enriched GO Terms of Interacting Partners?
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