TRIM32 and NDRG2

Number of citations of the paper that reports this interaction (PubMedID 25701873)
12

Data Source:
BioGRID (enzymatic study)

		TRIM32	NDRG2
Description		tripartite motif containing 32	NDRG family member 2
Image
GO Annotations	Cellular Component	Cell Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament	Nucleus Cytoplasm Golgi Apparatus Cytosol Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity	Molecular_function Protein Binding
	Biological Process	Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Actin Ubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Striated Muscle Cell Differentiation Axon Development Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cell Motility	Negative Regulation Of Cytokine Production Signal Transduction Regulation Of Vascular Endothelial Growth Factor Production Wnt Signaling Pathway Substantia Nigra Development Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Platelet-derived Growth Factor Production
Pathways		Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Bardet-Biedl syndrome (BBS)
GWAS		Estimated glomerular filtration rate ( 31015462)	Heart rate response to exercise ( 29769521) Hip circumference adjusted for BMI ( 28552196) Metabolite levels (small molecules and protein measures) ( 27005778) Resting heart rate ( 27798624)
Interacting Genes		41 interacting genes: ABI2 ATXN1 CLIP4 GLIS2 HSPA4 IQCB1 IRAK1 KCTD9 MID2 MYCN NDRG2 PDE9A PIAS3 PIAS4 PTCD2 PTPN11 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP STING1 SYT6 TOP1 TRIM23 TRIM27 TRIM5 TRIM72 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBQLN1 UBQLN4 VPS11 XIAP	6 interacting genes: ATP1B1 CLN8 CTDP1 MOB2 RABAC1 TRIM32
Entrez ID		22954	57447
HPRD ID		03797	17630
Ensembl ID		ENSG00000119401	ENSG00000165795
Uniprot IDs		A0A024R843 Q13049	Q9UN36
PDB IDs		2CT2 5FEY	2XMQ 2XMR 2XMS
Enriched GO Terms of Interacting Partners?
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