CCT5 and MCPH1

Number of citations of the paper that reports this interaction (PubMedID 29150431)
3

Data Source:
BioGRID (two hybrid)

		CCT5	MCPH1
Description		chaperonin containing TCP1 subunit 5	microcephalin 1
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GO Annotations	Cellular Component	Centrosome Cytosol Chaperonin-containing T-complex Microtubule Cell Body Extracellular Exosome	Cell Nucleoplasm Cytoplasm Microtubule Organizing Center
	Molecular Function	MRNA 3'-UTR Binding Protein Binding ATP Binding G-protein Beta-subunit Binding MRNA 5'-UTR Binding Beta-tubulin Binding Unfolded Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Protein Folding Binding Of Sperm To Zona Pellucida Response To Virus Positive Regulation Of Telomere Maintenance Via Telomerase Protein Stabilization Toxin Transport Positive Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of Protein Localization To Cajal Body Positive Regulation Of Telomerase RNA Localization To Cajal Body	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Mitotic Cell Cycle Arrest Neuronal Stem Cell Population Maintenance
Pathways		Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Folding of actin by CCT/TriC Association of TriC/CCT with target proteins during biosynthesis Association of TriC/CCT with target proteins during biosynthesis BBSome-mediated cargo-targeting to cilium Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Condensation of Prophase Chromosomes
Drugs
Diseases			Primary microcephaly (MCPH)
GWAS		Metabolite levels ( 23823483) Pain ( 22956598)	Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		18 interacting genes: ACTA1 ACTA2 ACTB CDC20 DUXAP9 ELP1 HDAC3 IMMT MCPH1 PDCL SUMO4 TBC1D17 TCP1 TERT THEG TP53 XRN1 ZNRD2	68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2
Entrez ID		22948	79648
HPRD ID		06468	06174
Ensembl ID		ENSG00000150753	ENSG00000147316
Uniprot IDs		B4DDU6 B4DX08 B4DYC8 B7ZAR1 E7ENZ3 E9PCA1 P48643 V9HW37	Q8NEM0
PDB IDs		5UYX 5UYZ 6NR8 6NR9 6NRA 6NRB 6NRC 6NRD 6QB8	2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z
Enriched GO Terms of Interacting Partners?
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