SNW1 and VDR

Number of citations of the paper that reports this interaction (PubMedID 9632709)
28

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		SNW1	VDR
Description		SNW domain containing 1	vitamin D receptor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cyclin/CDK Positive Transcription Elongation Factor Complex Nuclear Matrix Nuclear Body Nuclear Speck U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nuclear Chromatin Cell Nucleus Nucleoplasm Cytosol Receptor Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding Notch Binding Protein Binding Enzyme Binding Nuclear Hormone Receptor Binding Vitamin D Receptor Binding Retinoic Acid Receptor Binding SMAD Binding Androgen Receptor Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Vitamin D Binding Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Lithocholic Acid Receptor Activity Retinoid X Receptor Binding Vitamin D Response Element Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding Calcitriol Binding Lithocholic Acid Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II MRNA Splicing, Via Spliceosome Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Viral Process Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation By Host Of Viral Transcription Positive Regulation Of Notch Signaling Pathway Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of MRNA Splicing, Via Spliceosome Retinoic Acid Receptor Signaling Pathway Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Neurogenesis Positive Regulation Of Histone H3-K4 Methylation Regulation Of Vitamin D Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway Cellular Response To Retinoic Acid	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Skeletal System Development Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Calcium Ion Transport Cellular Calcium Ion Homeostasis Signal Transduction Multicellular Organism Development Lactation Negative Regulation Of Cell Proliferation Animal Organ Morphogenesis Positive Regulation Of Gene Expression Negative Regulation Of Keratinocyte Proliferation Positive Regulation Of Vitamin D 24-hydroxylase Activity Cell Differentiation Response To Lipid Bile Acid Signaling Pathway Vitamin D Metabolic Process Cholesterol Homeostasis Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Decidualization Intestinal Absorption Lipid Homeostasis Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Regulation Of Calcidiol 1-monooxygenase Activity Mammary Gland Branching Involved In Pregnancy Vitamin D Receptor Signaling Pathway Cellular Response To Lipopolysaccharide
Pathways		Pre-NOTCH Transcription and Translation Pre-NOTCH Transcription and Translation Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells NOTCH1 Intracellular Domain Regulates Transcription NOTCH1 Intracellular Domain Regulates Transcription SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway mRNA Splicing - Major Pathway RUNX3 regulates NOTCH signaling RUNX3 regulates NOTCH signaling NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription	Vitamin D (calciferol) metabolism Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs			Calcitriol Calcidiol Ergocalciferol Cholecalciferol Paricalcitol Dihydrotachysterol Alfacalcidol Calcipotriol 1-alpha, 25-dihydroxyl-20-epi-22-oxa-24, 26 ,27-trihomovitamin D3 Seocalcitol Cholesterol Inecalcitol Becocalcidiol CTA018 Eldecalcitol Doxercalciferol (1R,3R)-5-[(2E)-3-{(1S,3R)-2,2,3-trimethyl-3-[6,6,6-trifluoro-5-hydroxy-5-(trifluoromethyl)hex-3-yn-1-yl]cyclopentyl}prop-2-en-1-ylidene]cyclohexane-1,3-diol 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z) Vitamin D Curcumin
Diseases			Tuberculosis Localized autosomal recessive hypotrichosis
GWAS		Response to platinum-based chemotherapy in non-small-cell lung cancer ( 22872573)	Asthma (adult onset) ( 31036433) Gout ( 22179738) Gut microbiota (beta diversity) ( 27723756) Inflammatory bowel disease ( 23128233) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Menarche (age at onset) ( 25231870)
Interacting Genes		61 interacting genes: ACTN2 ASCC2 CEP55 CIR1 CXorf56 DAXX EP300 GOLGA2 HDAC2 IKBKG IKZF1 JDP2 KRT40 LRP2BP LZTS2 MAGEA1 MAPK6 MEN1 MFAP1 MSL1 MTUS2 NCOA1 NCOR1 NCOR2 NOTCH1 NOTCH3 NR0B1 NR0B2 OCLN PABPN1 PCBD2 PGR PPIL1 PRKAA2 RARA RB1 RBL1 RBL2 RBPJ RINT1 RXRA SART1 SIN3A SIRT1 SKI SMAD2 SMAD3 SMAD4 SNRNP200 SNU13 TEX11 TFIP11 TNNT1 TOP1 TRAF1 TRIM15 TTC14 VAV2 VDR VPS39 ZSCAN1	74 interacting genes: ACTN4 ACVR1 BAG1 CCND3 CDCA7L CDK7 CFH CLASRP COPS2 CREBBP CSNK2A1 CXXC5 FGR FOS FOXO3 GABARAPL1 GABARAPL2 GNPAT GOLM2 GRIP1 GTF2B HMGN3 HR JUN KDM5A LCOR MAPK1 MAPK3 MED1 MED12 MED14 MED23 MEOX2 MMRN2 MYC NCOA1 NCOA2 NCOA3 NCOA4 NCOA6 NCOR1 NCOR2 NKD2 NR0B2 NR1H2 NRIP1 NSD1 POLR2A POU1F1 POU2F1 PPARG PPP1CA PPP2CA PRCP PRKCSH PSMC5 RB1 RNF14 RUNX1 RUNX1T1 RXRA RXRB RXRG SIRT1 SMAD3 SNW1 SRC SRPK1 STAT1 TAF11 TDG TRIM24 TRIP13 ZBTB16
Entrez ID		22938	7421
HPRD ID		04340	03463
Ensembl ID		ENSG00000100603	ENSG00000111424
Uniprot IDs		G3V3A4 Q13573	F1D8P8 P11473
PDB IDs		5MQF 5XJC 5YZG 5Z58 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV	1DB1 1IE8 1IE9 1KB2 1KB4 1KB6 1S0Z 1S19 1TXI 1YNW 2HAM 2HAR 2HAS 2HB7 2HB8 3A2I 3A2J 3A3Z 3A40 3A78 3AUQ 3AUR 3AX8 3AZ1 3AZ2 3AZ3 3B0T 3CS4 3CS6 3KPZ 3M7R 3OGT 3P8X 3TKC 3VHW 3W0A 3W0C 3W0Y 3WGP 3WWR 3X31 3X36 4G2I 4ITE 4ITF 5GT4 5V39 5YSY 5YT2
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?